公开(公告)号：EP0145386A3

公开(公告)日：1986-11-26

申请号：EP84308143

申请日：1984-11-23

申请人： CITY OF HOPE NATIONAL MEDICAL CENTER

发明人： Clark, Brian R.

IPC分类号： C08J07/12 ,  G01N33/545

CPC分类号： C08J7/02 ,  C08J7/12 ,  C08J2325/06 ,  G01N33/545

摘要： Molded articles formed of polystyrene or other polymers containing an aromatic moiety can be derivatized on the surface of the article by subjecting the molded article to a chemical reaction wherein the reaction media utilizes tetramethylsulfone as the reactant solvent and a suitable substituent group which is substituted on to the aromatic moiety of the polystyrene or other polymer by electrophilic substitution. By choosing the substituent group to further include a leaving group, further substitution of the primary substituent can be effected normally by nucleophilic substitution reaction. In this way, biologically important molecules can be attached to a polystyrene or other aromatic containing polymer without effecting certain properties of the molded article such as its optical or spectroscopic clarity.

公开(公告)号：EP0145386B1

公开(公告)日：1991-05-15

申请号：EP84308143.1

申请日：1984-11-23

申请人： CITY OF HOPE NATIONAL MEDICAL CENTER

发明人： Clark, Brian R.

IPC分类号： C08J7/12 ,  G01N33/545

CPC分类号： C08J7/02 ,  C08J7/12 ,  C08J2325/06 ,  G01N33/545

公开(公告)号：EP0145386A2

公开(公告)日：1985-06-19

申请号：EP84308143.1

申请日：1984-11-23

申请人： CITY OF HOPE NATIONAL MEDICAL CENTER

发明人： Clark, Brian R.

IPC分类号： C08J7/12 ,  G01N33/545

CPC分类号： C08J7/02 ,  C08J7/12 ,  C08J2325/06 ,  G01N33/545

摘要： Molded articles formed of polystyrene or other polymers containing an aromatic moiety can be derivatized on the surface of the article by subjecting the molded article to a chemical reaction wherein the reaction media utilizes tetramethylsulfone as the reactant solvent and a suitable substituent group which is substituted on to the aromatic moiety of the polystyrene or other polymer by electrophilic substitution. By choosing the substituent group to further include a leaving group, further substitution of the primary substituent can be effected normally by nucleophilic substitution reaction. In this way, biologically important molecules can be attached to a polystyrene or other aromatic containing polymer without effecting certain properties of the molded article such as its optical or spectroscopic clarity.

摘要翻译： 由聚苯乙烯或含有芳族部分的其它聚合物形成的模制品可以通过使成型制品进行化学反应，其中反应介质使用四甲基砜作为反应物溶剂和适当的取代基 聚苯乙烯或其它聚合物的芳族部分通过亲电取代。 通过选择取代基进一步包括离去基团，可以通过亲核取代反应进一步取代一级取代基。 以这种方式，生物重要的分子可以连接到聚苯乙烯或其它含芳族聚合物，而不影响模制品的某些性质，例如其光学或光谱透明度。