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1.发明公开Microorganism producing O-acetyl-homoserine and the method of producing O-acetyl-homoserine using the microorganism 审中-公开生产O-乙酰 - 高丝氨酸的微生物以及使用该微生物生产O-乙酰 - 高丝氨酸的方法
公开(公告)号：EP2292783A2
公开(公告)日：2011-03-09
申请号：EP10250459.4
申请日：2010-03-11
发明人： Kim, So Young , Shin, Yong Uk , Heo, In Kyung , Kim, Hyun Ah , Seo, Chang Il , Kim, Ju Eun , Son, Sung Kwang , Lee, Sang Mok , Jhon, Sung Hoo , Lee, Han Jin , Na, Kwang Ho
CPC分类号： C12N9/1205 , C12N9/93 , C12P13/06 , C12Y207/01033 , C12Y602/01001
摘要： Disclosed herein are a microorganism strain capable of producing the L-methionine precursor O-acetyl homoserine in high yield and a method of producing O-acetyl homoserine using the same. The microorganism strain is a strain of Escherichia sp. in which an acetyl-CoA synthase gene ( acs ) and/or a pantothenate kinase gene ( coaA ) encoding a pantothenate kinase gene refractory to feedback inhibition by CoA is introduced and expressed.
摘要翻译： 本文公开了能够高产率生产L-甲硫氨酸前体O-乙酰高丝氨酸的微生物菌株以及使用该微生物菌株生产O-乙酰高丝氨酸的方法。 该微生物菌株是埃希氏菌属的一种菌株。 其中导入并表达编码对CoA的反馈抑制难以耐受的泛酸激酶基因的乙酰辅酶A合酶基因（acs）和/或泛酸激酶基因（coaA）。
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2.发明公开Microorganism producing O-acetyl-homoserine and the method of producing O-acetyl-homoserine using the microorganism 有权微生物O-乙酰 - 高丝氨酸生产以及使用该微生物制备O-乙酰 - 高丝氨酸的方法
公开(公告)号：EP2290051A1
公开(公告)日：2011-03-02
申请号：EP10250455.2
申请日：2010-03-11
发明人： Kim, So Young , Shin, Yong Uk , Heo, In Kyung , Kim, Hyun Ah , Seo, Chang Il , Kim, Ju Eun , Son, Sung Kwang , Lee, Sang Mok , Jhon, Sung Hoo , Lee, Han Jin , Na, Kwang Ho
CPC分类号： C12N9/1217 , C12N9/0006 , C12N9/0008 , C12N9/1029 , C12N9/1096 , C12N9/88 , C12P13/06
摘要： Disclosed is a strain of Escherichia sp., capable of producing O-acetyl homoserine in high yield, with the introduction and enhancement therein of the activity of: homoserine acetyl transferase, aspartokinase and homoserine dehydrogenase; and at least one enzyme selected from a group consisting of phosphoenolpyruvate carboxylase, aspartate aminotransferase and aspartate semi-aldehyde dehydrogenase. Also, a method of producing O-acetyl homoserine using the strain is provided.
摘要翻译： 。本发明公开了埃希氏菌属的菌株，能够以高产量产生O-乙酰高丝氨酸，随着在其中的活性的引入并增强的：高丝氨酸乙酰转移酶，天冬氨酸激酶和高丝氨酸脱氢酶; 和至少一种酶由选自由磷酸烯醇丙酮酸羧，天冬氨酸氨基转移酶和天冬氨酸半醛脱氢酶组成的组。 所以，提供了一种生产使用菌株O-乙酰高丝氨酸的方法。
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公开(公告)号：EP2444481B1
公开(公告)日：2018-11-28
申请号：EP11185852.8
申请日：2011-10-19
发明人： Shin, Soo An , Shin, Yong Uk , Kim, Hye Won , Kim, Sol , Um, Hye Won , Chang, Jin Sook , Bae, Hyun Ae , Jhon, Sung Hoo , Jo, Jae Hyun , Song, Byeong Cheol , Lee, Kyoung Min , Yang, Eun Bin
CPC分类号： C12N9/16 , C12N9/1085 , C12P13/06 , C12P13/12 , C12Y205/01065 , C12Y301/03003
摘要： The present invention relates to a method for production of cysteine or its derivatives using O-phosphoserine as an intermediate and recombinant microorganism for use in production of O-phosphoserine.
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4.发明授权Microorganism producing O-acetyl-homoserine and the method of producing O-acetyl-homoserine using the microorganism 有权微生物O-乙酰 - 高丝氨酸生产以及使用该微生物制备O-乙酰 - 高丝氨酸的方法
公开(公告)号：EP2290051B1
公开(公告)日：2016-09-14
申请号：EP10250455.2
申请日：2010-03-11
发明人： Kim, So Young , Shin, Yong Uk , Heo, In Kyung , Kim, Hyun Ah , Seo, Chang Il , Kim, Ju Eun , Son, Sung Kwang , Lee, Sang Mok , Jhon, Sung Hoo , Lee, Han Jin , Na, Kwang Ho
IPC分类号： C12N1/21 , C12N9/02 , C12N9/04 , C12N9/10 , C12N9/12 , C12N9/88 , C12P7/54 , C12P13/06 , C12P13/12
CPC分类号： C12N9/1217 , C12N9/0006 , C12N9/0008 , C12N9/1029 , C12N9/1096 , C12N9/88 , C12P13/06
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公开(公告)号：EP2292783B1
公开(公告)日：2018-08-15
申请号：EP10250459.4
申请日：2010-03-11
发明人： Kim, So Young , Shin, Yong Uk , Heo, In Kyung , Kim, Hyun Ah , Seo, Chang Il , Kim, Ju Eun , Son, Sung Kwang , Lee, Sang Mok , Jhon, Sung Hoo , Lee, Han Jin , Na, Kwang Ho
CPC分类号： C12N9/1205 , C12N9/93 , C12P13/06 , C12Y207/01033 , C12Y602/01001
摘要： Disclosed herein are a microorganism strain capable of producing the L-methionine precursor O-acetyl homoserine in high yield and a method of producing O-acetyl homoserine using the same. The microorganism strain is a strain of Escherichia sp. in which an acetyl-CoA synthase gene ( acs ) and/or a pantothenate kinase gene ( coaA ) encoding a pantothenate kinase gene refractory to feedback inhibition by CoA is introduced and expressed.
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6.发明公开MICROORGANISM PRODUCING O-ACETYL-HOMOSERINE AND THE METHOD OF PRODUCING O-ACETYL-HOMOSERINE USING THE MICROORGANISM 审中-公开微生物生产O-乙酰 - 高丝氨酸及使用微生物生产O-乙酰 - 高丝氨酸的方法
公开(公告)号：EP3269819A1
公开(公告)日：2018-01-17
申请号：EP17187852.3
申请日：2010-03-11
发明人： Kim, So Young , Shin, Yong Uk , Heo, In Kyung , Kim, Hyun Ah , Seo, Chang Il , Kim, Ju Eun , Son, Sung Kwang , Lee, Sang Mok , Jhon, Sung Hoo , Lee, Han Jin , Na, Kwang Ho
CPC分类号： C12N9/1205 , C12N9/93 , C12P13/06 , C12Y207/01033 , C12Y602/01001
摘要： Disclosed herein are a microorganism strain capable of producing the L-methionine precursor 0-acetyl homoserine in high yield and a method of producing 0-acetyl homoserine using the same. The microorganism strain is a strain of Escherichia sp. in which an acetyl-CoA synthase gene ( acs ) and/or a pantothenate kinase gene ( coaA ) encoding a pantothenate kinase gene refractory to feedback inhibition by CoA is introduced and expressed.
摘要翻译： 本文公开了能够高产率生产L-甲硫氨酸前体O-乙酰高丝氨酸的微生物菌株以及使用该微生物菌株生产O-乙酰高丝氨酸的方法。 该微生物菌株是埃希氏菌属的一种菌株。 其中导入并表达编码对CoA的反馈抑制难以耐受的泛酸激酶基因的乙酰辅酶A合酶基因（acs）和/或泛酸激酶基因（coaA）。
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7.发明公开Microorganism producing O-phosphoserine and method of producing L-cysteine or derivatives thereof from O-phosphoserine using the same 审中-公开O-磷酸丝氨酸生产微生物和方法，用于从O-磷酸丝氨酸生产L-半胱氨酸或其衍生物，从而
公开(公告)号：EP2444481A1
公开(公告)日：2012-04-25
申请号：EP11185852.8
申请日：2011-10-19
发明人： Shin, Soo An , Shin, Yong Uk , Kim, Hye Won , Kim, Sol , Um, Hye Won , Chang, Jin Sook , Bae, Hyun Ae , Jhon, Sung Hoo , Jo, Jae Hyun , Song, Byeong Cheol , Lee, Kyoung Min , Yang, Eun Bin
CPC分类号： C12N9/16 , C12N9/1085 , C12P13/06 , C12P13/12 , C12Y205/01065 , C12Y301/03003
摘要： The present invention relates to a method for production of cysteine or its derivatives using O-phosphoserine as an intermediate and recombinant microorganism for use in production of O-phosphoserine.
摘要翻译： 本发明涉及一种用于生产半胱氨酸或使用O-磷酸丝氨酸作为用于生产O-磷酸丝氨酸的使用中间和重组微生物及其衍生物的方法。
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8.发明公开Microorganism producing O-acetyl-homoserine and the method of producing O-acetyl-homoserine using the microorganism 审中-公开微生物O-乙酰 - 高丝氨酸生产以及使用该微生物制备O-乙酰 - 高丝氨酸的方法
公开(公告)号：EP2292783A3
公开(公告)日：2011-04-13
申请号：EP10250459.4
申请日：2010-03-11
发明人： Kim, So Young , Shin, Yong Uk , Heo, In Kyung , Kim, Hyun Ah , Seo, Chang Il , Kim, Ju Eun , Son, Sung Kwang , Lee, Sang Mok , Jhon, Sung Hoo , Lee, Han Jin , Na, Kwang Ho
CPC分类号： C12N9/1205 , C12N9/93 , C12P13/06 , C12Y207/01033 , C12Y602/01001
摘要： Disclosed herein are a microorganism strain capable of producing the L-methionine precursor O-acetyl homoserine in high yield and a method of producing O-acetyl homoserine using the same. The microorganism strain is a strain of Escherichia sp. in which an acetyl-CoA synthase gene ( acs ) and/or a pantothenate kinase gene ( coaA ) encoding a pantothenate kinase gene refractory to feedback inhibition by CoA is introduced and expressed.
摘要翻译： 在所公开的是能够产生高收率的L-蛋氨酸前体O-乙酰高丝氨酸和生产使用相同的O-乙酰高丝氨酸的方法的微生物菌株。 的微生物菌株是埃希氏菌属的菌株。 在哪合酶基因（ACS）到乙酰-CoA和/或编码的泛酸激酶基因耐火对CoA的反馈抑制的泛酸激酶基因（coaA）两者被引入并过量表达。
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