公开(公告)号：EP2339490A1

公开(公告)日：2011-06-29

申请号：EP10183918.1

申请日：2001-02-09

申请人： CNS Response, Inc.

发明人： Suffin, Stephen ,  Emory, Hamlin W.

IPC分类号： G06F19/00 ,  A61B5/04

CPC分类号： A61B5/4833 ,  A61B5/0006 ,  A61B5/0476 ,  A61B5/048 ,  A61B5/0484 ,  A61B5/1104 ,  A61B5/16 ,  A61B5/165 ,  A61B5/7257 ,  A61B5/7264 ,  A61B5/7275 ,  G06F19/00 ,  G06F19/3456 ,  G06F19/3481 ,  G16H10/60 ,  G16H15/00

摘要： The present invention relates to a method for determining medication efficacy, comprising:
a) providing;
i) a patient having a physiologic brain imbalance, wherein said imbalance is identified using a first electroencephalography recording, and
ii) a medication; and,

b) converting said first electroencephalography recording to at least one first multivariate outcome measurement wherein said first outcome measurement comprises a plurality of first univariate Z scores, wherein said first multivariate outcome measurement is derived from a frequency band selected from the group consisting of delta, theta, alpha, and beta;
c) administering said medication to said patient;
d) obtaining a second electroencephalography recording from said patient and converting said second electroencephalography recording to at least one second multivariable outcome measurement wherein said second outcome measurement comprises a plurality of second univariate Z scores, wherein said second multivariate outcome measurement is derived from a frequency band selected from the group consisting of delta, theta, alpha, and beta; and
e) comparing said first multivariate outcome measurement with said second multivariate outcome measurement wherein a differential change between said first and second measurement determines said medication efficacy.

摘要翻译： 本发明涉及一种用于确定药物疗效的方法，包括：a）提供; i）具有生理性脑不平衡的患者，其中使用第一脑电图记录识别所述不平衡，和ii）药物; 以及b）将所述第一脑电图记录转换为至少一个第一多变量结果测量，其中所述第一结果测量包括多个第一单变量Z分数，其中所述第一多变量结果测量从选自以下的频带导出： ，θ，α和β; c）向所述患者施用所述药物; d）从所述患者获得第二次脑电图记录并将所述第二脑电图记录转换为至少一个第二多变量结果测量，其中所述第二结果测量包括多个第二单变量Z分数，其中所述第二多变量结果测量从频带 选自由δ，θ，α和β组成的组; 以及e）将所述第一多变量结果测量与所述第二多变量结果测量进行比较，其中所述第一和第二测量之间的差异变化确定所述药物功效。

公开(公告)号：EP2275959A3

公开(公告)日：2011-04-06

申请号：EP10183881.1

申请日：2002-07-11

申请人： CNS Response, Inc.

发明人： Suffin, Stephen ,  Emory, Hamlin W. ,  Brand, Leonard J.

IPC分类号： G06F19/00 ,  A61B5/04

CPC分类号： A61B5/4076 ,  A61B5/0006 ,  A61B5/0476 ,  A61B5/411 ,  A61B5/4833 ,  A61B5/7257 ,  A61B5/7264 ,  G06F19/00 ,  G06F19/3481 ,  G16H15/00 ,  G16H50/20 ,  G16H50/70

摘要： The present invention relates to a method of screening a therapeutic agent for therapeutic effectiveness, comprising:
a) providing:
i) at least one patient, wherein said patient has a first disorder associated with a first set of electroencephalographic information;
ii) a plurality of reference patients comprising at least one second disorder associated with a second set of electroencephalographic information;
iii) a therapeutic agent, wherein said agent has no known therapeutic effectiveness for said at least one second disorder; and

b) treating said patient with said agent, wherein said agent is therapeutically effective for said first disorder;
c) identifying, using a computer a similarity between said first set of electroencephalographic information and said second set of electroencephalographic information; and d. indicating said agent as having therapeutic effectiveness for said at least one second disorder based upon said similarity in said reference patients.

公开(公告)号：EP2275959A2

公开(公告)日：2011-01-19

申请号：EP10183881.1

申请日：2002-07-11

申请人： CNS Response, Inc.

发明人： Suffin, Stephen ,  Emory, Hamlin W. ,  Brand, Leonard J.

IPC分类号： G06F19/00 ,  A61B5/04

CPC分类号： A61B5/4076 ,  A61B5/0006 ,  A61B5/0476 ,  A61B5/411 ,  A61B5/4833 ,  A61B5/7257 ,  A61B5/7264 ,  G06F19/00 ,  G06F19/3481 ,  G16H15/00 ,  G16H50/20 ,  G16H50/70

摘要： The present invention relates to a method of screening a therapeutic agent for therapeutic effectiveness, comprising:
a) providing:
i) at least one patient, wherein said patient has a first disorder associated with a first set of electroencephalographic information;
ii) a plurality of reference patients comprising at least one second disorder associated with a second set of electroencephalographic information;
iii) a therapeutic agent, wherein said agent has no known therapeutic effectiveness for said at least one second disorder; and

b) treating said patient with said agent, wherein said agent is therapeutically effective for said first disorder;
c) identifying, using a computer a similarity between said first set of electroencephalographic information and said second set of electroencephalographic information; and d. indicating said agent as having therapeutic effectiveness for said at least one second disorder based upon said similarity in said reference patients.

摘要翻译： 本发明涉及一种筛选用于治疗有效性的治疗剂的方法，包括：a）提供：i）至少一名患者，其中所述患者具有与第一组脑电图信息相关的第一种病症; ii）多个参考患者，包括与第二组脑电图信息相关联的至少一种第二病症; iii）治疗剂，其中所述药剂对于所述至少一种第二种病症没有已知的治疗有效性; 和b）用所述药物治疗所述患者，其中所述药剂对于所述第一种病症是治疗有效的; c）使用计算机识别所述第一组脑电图信息和所述第二组脑电图信息之间的相似性; 和d。 指示所述试剂基于所述参考患者的所述相似性具有对所述至少一种第二病症的治疗有效性。