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1.发明授权ANDROSTANE AND PREGNANE SERIES FOR ALLOSTERIC MODULATION OF GABA RECEPTOR 失效雄甾烷和PREGNANSERIEN用于GABA受体的变构调节
公开(公告)号：EP0808325B1
公开(公告)日：2001-01-17
申请号：EP95942879.8
申请日：1995-11-22
申请人： COCENSYS, INC.
发明人： LAN, Nancy, C. , GEE, Kelvin, W. , BOLGER, Michael, B. , TAHIR, Hasan , PURDY, Robert , UPASANI, Ravindra, B.
CPC分类号： C07J41/005 , C07J5/0015 , C07J7/002 , C07J7/007 , C07J9/00
摘要： Methods, compositions, and compounds for modulating the GABAA receptor-chloride ionophore complex to alleviate stress, anxiety, seizures, mood disorders, PMS and PND and to induce anesthesia.
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2.发明授权4-BENZYL PIPERIDINE ALKYLSULFOXIDE HETEROCYCLES AND THEIR USE AS SUBTYPE-SELECTIVE NMDA RECEPTOR ANTAGONISTS 有权4-苄基哌啶烷基亚砜杂环及其作为亚型选择性NMDA受体拮抗剂
公开(公告)号：EP1089735B1
公开(公告)日：2005-06-08
申请号：EP99931887.6
申请日：1999-06-25
IPC分类号： A61K31/445 , C07D401/12 , C07D407/12 , C07D409/12 , C07D411/12 , C07D413/12 , C07D417/12 , A61P25/16 , A61P25/28 , A61P9/10
CPC分类号： C07D413/12 , A61K31/445 , A61K31/195 , A61K2300/00
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3.发明公开4-BENZYL PIPERIDINE ALKYLSULFOXIDE HETEROCYCLES AND THEIR USE AS SUBTYPE-SELECTIVE NMDA RECEPTOR ANTAGONISTS 有权4-苄基哌啶烷基亚砜杂环及其作为亚型选择性NMDA受体拮抗剂
公开(公告)号：EP1089735A1
公开(公告)日：2001-04-11
申请号：EP99931887.6
申请日：1999-06-25
IPC分类号： A61K31/445 , C07D401/12 , C07D407/12 , C07D409/12 , C07D411/12 , C07D413/12 , C07D417/12
CPC分类号： C07D413/12 , A61K31/445 , A61K31/195 , A61K2300/00
摘要： Novel 4-Benzyl piperidine alkylsulfoxide heterocycles are disclosed and their use as subtype selective NMDA receptor antagonists, particularly for the treatment of Parkinson's disease, most preferably in combination with L-DOPA.
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4.发明公开ANDROSTANE AND PREGNANE SERIES FOR ALLOSTERIC MODULATION OF GABA RECEPTOR 失效雄甾烷和PREGNANSERIEN用于GABA受体的变构调节
公开(公告)号：EP0808325A1
公开(公告)日：1997-11-26
申请号：EP95942879.0
申请日：1995-11-22
申请人： COCENSYS, INC.
发明人： LAN, Nancy, C. , GEE, Kelvin, W. , BOLGER, Michael, B. , TAHIR, Hasan , PURDY, Robert , UPASANI, Ravindra, B.
CPC分类号： C07J41/005 , C07J5/0015 , C07J7/002 , C07J7/007 , C07J9/00
摘要： Methods, compositions, and compounds for modulating the GABAA receptor-chloride ionophore complex to alleviate stress, anxiety, seizures, mood disorders, PMS and PND and to induce anesthesia.
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公开(公告)号：EP0837874A2
公开(公告)日：1998-04-29
申请号：EP96919372.0
申请日：1996-06-06
申请人： Cocensys, Inc.
CPC分类号： C07J31/006 , C07J1/0007 , C07J1/0029 , C07J1/0055 , C07J1/0077 , C07J17/00 , C07J21/00 , C07J41/0005 , C07J41/005 , C07J43/003
摘要： The invention relates to 3α-hydroxy, 17-(un)substituted derivatives of the androstane series and 3α-hydroxy, 21-substituted derivatives of the pregnane series. These derivatives are capable of acting at a recently identified site on the GRC, thereby modulating brain excitability in a manner that will alleviate stress, anxiety, insomnia, mood disorders that are amenable to GRC-active agents (such as depression) and seizure activity. The steroid derivatives of this invention are those having general structural formula (I), wherein R, R1, R2, R3, R4, R5, R6, R7, R8, R9 and R10 are further defined herein and the dotted lines are single or double bonds. The structure includes androstanes pregnanes (R4 = methyl), 19-norandrostanes, and norpregnanes (R4 = H).
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公开(公告)号：EP0701444A1
公开(公告)日：1996-03-20
申请号：EP94918659.0
申请日：1994-05-23
申请人： COCENSYS, INC.
发明人： GEE, Kelvin W. , LAN, Nancy Tsai-Yun , UPASANI, Ravindra, B. , HOGENKAMP, Derk, J. , PURDY, Robert , BOLGER, Michael, B. , TAHIR, Hasan
CPC分类号： C07J43/003 , A61K31/56 , A61K31/565 , A61K31/57 , A61K31/575 , A61K31/58 , C07J5/0015 , C07J7/002 , C07J7/0085 , C07J17/00 , C07J31/006 , C07J33/002 , C07J41/005 , C07J41/0094 , C07J51/00
摘要： Methods and compositions for interacting with the GABAA receptor complex to induce sleep in humans using certain 5 3α-hydroxy-5-reduced steroid derivatives.
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