公开(公告)号：EP3178811B1

公开(公告)日：2018-10-31

申请号：EP15306966.1

申请日：2015-12-09

申请人： COMMISSARIAT À L'ÉNERGIE ATOMIQUE ET AUX ÉNERGIES ALTERNATIVES

发明人： VON WOLFF, Niklas ,  CHAR, Joëlle ,  CANTAT, Thibault

IPC分类号： C07D213/71 ,  C07C315/04 ,  C07D265/30

CPC分类号： C07D295/26 ,  C07C315/04 ,  C07D213/71 ,  C07D265/30 ,  C07C317/14 ,  C07C317/22

摘要： The present invention relates to a one pot single step process for the synthesis of a compound containing a sulfonyl functional group, in particular a sulfone or a sulfonamide, comprising the step of mixing together a silane, an SO 2 source, an electrophilic compound, an activating compound and optionally a metal catalyst. Labeled compounds containing a sulfonyl functional group, in particular labeled sulfones or sulfonamides can also be synthesized by the process of the invention. The present invention also concerns the use of unlabeled or labeled sulfonyl containing compounds, in particular labeled or unlabeled sulfones and sulfonamides, obtained by a process according to the invention in the manufacture of vitamins, pharmaceuticals, adhesives, acrylic fibers and synthetic leathers, pesticides, and fertilizers, for example. The present invention further relates to a process for producing tracers and tracers comprising a step of synthesis of a labeled sulfonyl containing compounds, in particular labeled sulfones and sulfonamides, obtained by a process according to the invention.

公开(公告)号：EP3178811A1

公开(公告)日：2017-06-14

申请号：EP15306966.1

申请日：2015-12-09

申请人： COMMISSARIAT À L'ÉNERGIE ATOMIQUE ET AUX ÉNERGIES ALTERNATIVES

发明人： VON WOLFF, Niklas ,  CHAR, Joëlle ,  CANTAT, Thibault

IPC分类号： C07D213/71 ,  C07C315/04 ,  C07D265/30

CPC分类号： C07D295/26 ,  C07C315/04 ,  C07D213/71 ,  C07D265/30 ,  C07C317/14 ,  C07C317/22

摘要： The present invention relates to a one pot single step process for the synthesis of a compound containing a sulfonyl functional group, in particular a sulfone or a sulfonamide, comprising the step of mixing together a silane, an SO 2 source, an electrophilic compound, an activating compound and optionally a metal catalyst. Labeled compounds containing a sulfonyl functional group, in particular labeled sulfones or sulfonamides can also be synthesized by the process of the invention.
The present invention also concerns the use of unlabeled or labeled sulfonyl containing compounds, in particular labeled or unlabeled sulfones and sulfonamides, obtained by a process according to the invention in the manufacture of vitamins, pharmaceuticals, adhesives, acrylic fibers and synthetic leathers, pesticides, and fertilizers, for example.
The present invention further relates to a process for producing tracers and tracers comprising a step of synthesis of a labeled sulfonyl containing compounds, in particular labeled sulfones and sulfonamides, obtained by a process according to the invention.

摘要翻译： 本发明涉及用于合成含有磺酰基官能团，特别是砜或磺酰胺的化合物的一锅法单步法，其包括将硅烷，SO 2源，亲电子化合物，活化剂 化合物和任选的金属催化剂。 含有磺酰基官能团，特别是标记的砜或磺酰胺的标记化合物也可以通过本发明的方法合成。 本发明还涉及根据本发明的方法获得的未标记或标记的含磺酰基的化合物，特别是标记的或未标记的砜和磺酰胺在制备维生素，药物，粘合剂，丙烯酸纤维和合成皮革，杀虫剂， 和肥料，例如。 本发明进一步涉及生产示踪剂和示踪剂的方法，其包括合成通过根据本发明的方法获得的含有标记的磺酰基的化合物，特别是标记的砜和磺酰胺的步骤。