公开(公告)号：EP1257550A1

公开(公告)日：2002-11-20

申请号：EP01908817.8

申请日：2001-02-05

申请人： COR THERAPEUTICS, INC.

发明人： SCARBOROUGH, Robert, M. ,  JANTZEN, Hans-Michael ,  HUANG, Wolin ,  SEDLOCK, David, M. ,  MARLOWE, Charles, K.

IPC分类号： C07D417/12 ,  C07D411/12 ,  C07D417/14 ,  C07D401/04 ,  C07D239/22 ,  A61P9/00 ,  A61K31/40 ,  A61K31/38 ,  A61K31/44 ,  A61K31/495 ,  A61K31/425 ,  A61K31/55 ,  C07D521/00

CPC分类号： C07D239/22 ,  C07D239/48 ,  C07D239/50 ,  C07D333/34 ,  C07D401/04 ,  C07D401/12 ,  C07D405/12 ,  C07D409/12 ,  C07D409/14 ,  C07D417/12 ,  C07D495/04

摘要： Novel compounds of formula (I) to (VI), which more particularly include sulfonylura derivatives, sulfonylthiourea derivatives, sulfonylguanidine derivatives, sulfonylcyanoguanidine derivatives, thioacylsulfonamide derivatives, and acylsulfonamide derivatives which are effective platelet ADP receptor inhibitors. These derivatives may be used in various pharmaceutical compositions, and are particularly effective for the prevention and/or treatment of cardiovascular diseases, particularly those diseases related to thrombosis. The invention also relates to a method for preventing or treating thrombosis in a mammal comprising the step of administering a therapeutically effective amount of a compound of formulae (I)-(VI), or a pharmaceutically acceptable salt thereof.