专利检索 ap:("CORNELL RESEARCH FOUNDATION, INC.") AND inv:"SMITH, Caroline, L." 第 1 页

1.

发明公开
PHARMACOTHERAPY FOR VASCULAR DYSFUNCTION ASSOCIATED WITH DEFICIENT NITRIC OXIDE BIOACTIVITY 审中-公开
标题翻译：药物治疗血管功能障碍相关的硝酸赤字生物活性相关的

公开(公告)号：EP1351674A1

公开(公告)日：2003-10-15

申请号：EP01969029.6

申请日：2001-04-03

申请人： CORNELL RESEARCH FOUNDATION, INC.

发明人： GROSS, Steven, S. , SMITH, Caroline, L.

IPC分类号： A61K31/195 , A61K31/155

CPC分类号： A61K31/44 , A61K31/155 , A61K31/198 , A61K31/445 , A61K31/495 , A61K31/505 , A61K31/519 , A61K31/525 , A61K31/70 , A61K2300/00

摘要： A patient with a disorder involving endothelial dysfunction associated with deficient nitric oxide bioactivity, e.g., coronary artery disease, atherosclerosis, hypertension, diabetes or neurodegenerative condition stemming from ischemia and/or inflammation, is treated by administering nitric oxide bioactivity increasing agent having formula (I) wherein R?1, R2, R3 and R4¿ are the same or different and are independently selected from the group consisting hydrogen, amino, imino, alkyl, substituted alkyl, phenyl, substituted phenyl, cycloalkyl, benzyl, acyl, pyridyl, piperidyl, amino acid, lipid and carbohydrate and where R?3 and R4¿ can optionally join to form a ring. Treating agents include Nφ-hydroxyarginine and hydroxyguanidine.