公开(公告)号：EP1307235A2

公开(公告)日：2003-05-07

申请号：EP01959331.8

申请日：2001-07-30

申请人： CORNELL RESEARCH FOUNDATION, INC. ,  Hospital for Special Surgery ,  GENVEC, INC.

发明人： CRYSTAL, Ronald, G. ,  HIDAKA, Chisa ,  BOACHILE-ADJEI, Oheneba ,  RAWLINS, Bernard, A. ,  KOVESDI, Imre

IPC分类号： A61K48/00

CPC分类号： A61K38/1875 ,  A61K38/18 ,  A61K38/1841 ,  A61K38/1866 ,  A61K48/00 ,  C12N2799/022 ,  A61K2300/00

摘要： The present invention is directed to a method for enhancing bone density or formation. In accordance with the method, a nucleic acid encoding an angiogenic protein is administered to a cell in a region of a bone such that the nucleic acid is expressed to produce the angiogenic protein, whereby bone density or formation is enhanced within the region. Optionally, a nucleic acid encoding and osteogenic protein is administered to a cell within the same region such that the nucleic acid is expressed to produce the osteogenic protein. The method can be employed to produce a bone graft having a cell harboring an exogenous nucleic acid encoding an angiogenic protein and, optionally, a cell harboring a nucleic acid encoding an osteogenic protein. To facilitate the inventive method, the invention also pertains to a recombinant viral vector having a nucleic acid encoding an angiogenic protein and a nucleic acid encoding an osteogenic protein.