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公开(公告)号：EP0756709A1
公开(公告)日：1997-02-05
申请号：EP95919112.0
申请日：1995-04-11
申请人： COULTER CORPORATION
CPC分类号： G01N33/54333 , G01N33/553 , G01N33/56972 , G01N33/574 , Y10S436/824
摘要： A separation procedure for separating a selected desired or undesired population from a biological sample utilizing relatively heavy, dense particles and gravity sedimentation. The particles have one or more reactants bound thereto which are specific to and will bind with the selected population. The particles preferably are mixed with the sample by repeatedly causing the particles to settle through a substantial portion of the sample to bind to the selected population. The particles with the bound selected population then are allowed to preferentially settle in the sample and the supernatant including the non-selected population is separated from the particles with the selected population bound thereto. The particles can be heated for sterilization and endotoxin removal.
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2.发明公开METHOD AND APPARATUS FOR BULK ENRICHMENT OF A POPULATION OR SUBPOPULATION OF CELLS 失效方法和设备细胞群或亚群的富集BULK
公开(公告)号：EP0877941A1
公开(公告)日：1998-11-18
申请号：EP96943478.0
申请日：1996-11-05
CPC分类号： G01N33/5375 , G01N33/54313 , G01N33/553 , G01N33/56966 , G01N33/56972
摘要： A cell population or subpopulation enrichment procedure (10) for separating undesired populations or subpopulations from a biological sample (12) utilizing relatively heavy, dense particles (14) and gravity sedimentation. The particles have one or more reactants bound thereto which are specific to and will bind with the selected population or subpopulation to be eliminated from the sample. The particles preferably are mixed with the sample by repeatedly causing the particles to settle through a substantial portion of the sample to bind to the selected population. The particles with the bound selected population to be eliminated then are allowed to preferentially settle in the sample and the supernatant including the enriched population or subpopulation is separated from the particles with the population to be eliminated bound thereto. The enriched population supernatant can then be analyzed, utilized as is, have other populations or subpopulations removed or have additional amounts of remaining cells of the previously eliminated populations removed in additional steps.
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