公开(公告)号：EP1692101B1

公开(公告)日：2011-07-06

申请号：EP03780487.9

申请日：2003-12-23

申请人： Council of Scientific and Industrial Research

发明人： SANGITA ,  KUMAR, Atul ,  SINGH, Man Mohan ,  JAIN, Girish Kumar ,  MURTHY, Puvvada Sri Ramchandra ,  RAY, Suprabhat

IPC分类号： C07C317/22 ,  C07C317/24 ,  C07C323/19 ,  C07C323/22 ,  C07C323/25 ,  C07D295/088 ,  A61K31/10 ,  A61K31/12 ,  A61K31/145 ,  A61K31/222 ,  A61K31/40 ,  A61K31/4453 ,  A61P5/30

CPC分类号： C07D295/088 ,  C07C317/22 ,  C07C317/24 ,  C07C323/19 ,  C07C323/22 ,  C07C323/25

摘要： The present invention relates to the field of pharmaceuticals and organic chemistry and provides novel mercapto phenyl naphthyl methane derivatives, their pharmaceutically acceptable salts and compositions and preparation thereof, that are useful for the prevention or treatment of various medical indications associated with estrogen dependent diseases or syndromes related to osteoporosis, bone loss, bone formation, cardiovascular disorders, neurodegenerative disorders, menopausal disorders, physiological disorders, diabetes disorders, prostatic carcinoma, cancer of breast, cancer of uterus, cancer of the cervix and cancer of the colon, threatened or habitual abortion, obesity, ovarian development or function, post-partum lactation and depression.

摘要翻译： 本发明涉及药物和有机化学领域，并且提供了新的巯基苯基萘甲烷衍生物，其药学上可接受的盐和组合物及其制备，其可用于预防或治疗与雌激素依赖性疾病或综合征有关的各种医学适应症 与骨质疏松症，骨丢失，骨形成，心血管疾病，神经退行性疾病，绝经期疾病，生理疾病，糖尿病疾病，前列腺癌，乳房癌，子宫癌，子宫颈癌和结肠癌，受威胁或习惯性流产有关 ，肥胖，卵巢发育或功能，产后泌乳和抑郁症。

公开(公告)号：EP1692101A1

公开(公告)日：2006-08-23

申请号：EP03780487.9

申请日：2003-12-23

申请人： COUNCIL OF SCIENTIFIC AND INDUSTRIAL RESEARCH

发明人： SANGITA ,  KUMAR, Atul ,  SINGH, Man Mohan ,  JAIN, Girish Kumar ,  MURTHY, Puvvada Sri Ramchandra ,  RAY, Suprabhat

IPC分类号： C07C317/22 ,  C07C317/24 ,  C07C323/19 ,  C07C323/22 ,  C07C323/25 ,  C07D295/088 ,  A61K31/10 ,  A61K31/12 ,  A61K31/145 ,  A61K31/222 ,  A61K31/40 ,  A61K31/4453 ,  A61P5/30

CPC分类号： C07D295/088 ,  C07C317/22 ,  C07C317/24 ,  C07C323/19 ,  C07C323/22 ,  C07C323/25

摘要： The present invention relates to the field of pharmaceuticals and organic chemistry and provides novel mercapto phenyl naphthyl methane derivatives, their pharmaceutically acceptable salts and compositions and preparation thereof, that are useful for the prevention or treatment of various medical indications associated with estrogen dependent diseases or syndromes related to osteoporosis, bone loss, bone formation, cardiovascular disorders, neurodegenerative disorders, menopausal disorders, physiological disorders, diabetes disorders, prostatic carcinoma, cancer of breast, cancer of uterus, cancer of the cervix and cancer of the colon, threatened or habitual abortion, obesity, ovarian development or function, post-partum lactation and depression.