METAL COMPOUNDS, MIXED OR SULPHATED, AS PHOSPHATE BINDERS
    4.
    发明公开
    METAL COMPOUNDS, MIXED OR SULPHATED, AS PHOSPHATE BINDERS 有权
    Aluminiumfreie gemischte Metallzusammensetzungen als Phosphatbindemittel

    公开(公告)号:EP1015002A1

    公开(公告)日:2000-07-05

    申请号:EP98944055.7

    申请日:1998-09-18

    申请人: CROSFIELD LIMITED

    IPC分类号: A61K33/26 A61K33/06 A61K33/24

    摘要: A mixed metal compound for pharmaceutical use is free from aluminium and has a phosphate binding capacity of at least 30 %, by weight of the total weight of phosphate present, over a pH range of from 2-8. The compound is especially useful for treatment of hyperphosphataemia. The metals are preferably iron (III) and at least one of calcium, magnesium, lanthanum and cerium. A metal sulphate for pharmaceutical use is selected from at least one of calcium, lanthanum and cerium sulphate compounds and has a phosphate binding capacity of at least 30 % by weight of the total phosphate present, over a pH range from 2-8.

    摘要翻译: 用于药物的混合金属化合物不含铝,并且在2-8的pH范围内具有至少30重量%的磷酸盐存在的总重量的磷酸盐结合能力。 该化合物特别适用于治疗高磷血症。 金属优选为铁(III)和钙,镁,镧和铈中的至少一种。 用于药物用途的金属硫酸盐选自钙,镧和硫酸铈化合物中的至少一种,并且在2-8的pH范围内具有至少30重量%的存在的总磷酸盐的磷酸盐结合能力。