公开(公告)号：EP2453735B1

公开(公告)日：2015-07-08

申请号：EP10720980.1

申请日：2010-05-26

申请人： Calimmune Inc.

发明人： BRETON, Louis Randall ,  CHEN, Irvin ,  AN, Dong Sung ,  SYMONDS, Geoffrey P. ,  BOYD, Maureen ,  MILLINGTON, Michelle

IPC分类号： A01K67/027 ,  A61K35/28 ,  A61K48/00 ,  C07K14/00 ,  C07K14/16 ,  C07K14/47 ,  C12N9/90 ,  C12N15/85 ,  C12N15/867 ,  C12N15/113

CPC分类号： A61K35/28 ,  A01K67/0271 ,  A01K2207/12 ,  A01K2227/105 ,  A01K2267/0337 ,  A61K31/713 ,  A61K38/162 ,  A61K48/00 ,  A61K48/0058 ,  A61K2035/124 ,  C07K14/00 ,  C07K14/4702 ,  C07K2319/03 ,  C12N5/0647 ,  C12N7/00 ,  C12N9/90 ,  C12N15/1138 ,  C12N15/86 ,  C12N2310/14 ,  C12N2310/531 ,  C12N2320/30 ,  C12N2320/31 ,  C12N2510/00 ,  C12N2740/16021 ,  C12N2740/16033 ,  C12N2740/16043 ,  C12N2740/16071 ,  C12N2740/16171 ,  C12N2740/16222 ,  C12N2740/16234 ,  C12N2830/008 ,  C12N2830/85

摘要： The present invention provides an expression vector for preventing or inhibiting HlV entry, fusion or replication in mammalian cells. In particular, the invention provides a recombinant retroviral vector that encodes an inhibitor of a HlV co-receptor, such as CCR5 or CXCR4, and a protein that inhibits HIV fusion to target cells and/or HIV replication. Pharmaceutical compositions comprising such constructs and methods of use thereof to prevent or treat HIV infection in a patient are also disclosed.

公开(公告)号：EP2453735A2

公开(公告)日：2012-05-23

申请号：EP10720980.1

申请日：2010-05-26

申请人： Calimmune Inc.

发明人： CHEN, Irvin ,  AN, Dong Sung ,  MILLINGTON, Michelle ,  BOYD, Maureen ,  SYMONDS, Geoffrey P. ,  BRETON, Louis Randall

IPC分类号： A01K67/027 ,  A61K35/28 ,  A61K48/00 ,  C07K14/00 ,  C07K14/16 ,  C07K14/47 ,  C12N9/90 ,  C12N15/85 ,  C12N15/867 ,  C12N15/113

CPC分类号： A61K35/28 ,  A01K67/0271 ,  A01K2207/12 ,  A01K2227/105 ,  A01K2267/0337 ,  A61K31/713 ,  A61K38/162 ,  A61K48/00 ,  A61K48/0058 ,  A61K2035/124 ,  C07K14/00 ,  C07K14/4702 ,  C07K2319/03 ,  C12N5/0647 ,  C12N7/00 ,  C12N9/90 ,  C12N15/1138 ,  C12N15/86 ,  C12N2310/14 ,  C12N2310/531 ,  C12N2320/30 ,  C12N2320/31 ,  C12N2510/00 ,  C12N2740/16021 ,  C12N2740/16033 ,  C12N2740/16043 ,  C12N2740/16071 ,  C12N2740/16171 ,  C12N2740/16222 ,  C12N2740/16234 ,  C12N2830/008 ,  C12N2830/85

摘要： The present invention provides an expression vector for preventing or inhibiting HlV entry, fusion or replication in mammalian cells. In particular, the invention provides a recombinant retroviral vector that encodes an inhibitor of a HlV co-receptor, such as CCR5 or CXCR4, and a protein that inhibits HIV fusion to target cells and/or HIV replication. Pharmaceutical compositions comprising such constructs and methods of use thereof to prevent or treat HIV infection in a patient are also disclosed.