利索-全球专利检索

  1. 登录
  2. 注册

搜索结果

2 条记录 (耗时 0.01 秒)

    Specific binding members for human transforming growth factor beta; materials and methods
    1.
    发明公开
    Specific binding members for human transforming growth factor beta; materials and methods 失效
    人类TGF-β的材料和方法特异性结合的合作伙伴

    公开(公告)号：EP0945464A1

    公开(公告)日：1999-09-29

    申请号：EP99102166.8

    申请日：1996-10-07

    申请人： Cambridge Antibody Technology Limited

    发明人： Thompson, Julia Elizabeth ,  Williams, Andrew James ,  Vaughan, Tristan John ,  Green, Jonathan Alexander ,  Johnson, Kevin Stuart ,  Tempest, Philip Ronald ,  Wilton, Alison Jane

    IPC分类号： C07K16/22

    CPC分类号： C07K16/22 ,  A61K38/00 ,  C07K2317/21 ,  C07K2317/622

    摘要： Specific binding members comprising human antibody antigen binding domains specific for human transforming growth factor beta (TGFβ) bind specifically isoforms TGFβ2 and TGFβ1 or both, preferentially compared with TGFβ3. Specific binding members may be isolated and utilised in the treatment of disease, particularly fibrotic disease and also immune/inflammatory diseases. Therapeutic utility is demonstrated using in vitro and in vivo models. Full sequence and binding information is provided, including epitope sequence information for a particularly advantageous specific binding member which binds the active form of TGFβ2, neutralising its activity, but does not bind the latent form.

    摘要翻译： 包含人抗体的抗原结合特异性的人转化生长因子β（TGF测试版）特异性结合亚型TGF的β2和TGF的β1或两个结构域特异性结合成员，优先与TGF测试相比3.特异性结合成员可以在被分离和利用 治疗疾病，特别是纤维化疾病并因此免疫/炎性疾病。 治疗效用，使用体外和体内模型中以实例阐述。 全序列，并且设置bindingInformation，包括其结合TGFβ2受体，中性伊辛其活性的活性形式，但不结合的潜在形式的特别有利的特异性结合成员的表位的序列信息。