利索-全球专利检索

  1. 登录
  2. 注册

搜索结果

8 条记录 (耗时 0.013 秒)

    Xanthene-based colorant compound
    5.
    发明公开
    Xanthene-based colorant compound 有权
    Xanthen Farbstoffverbindung

    公开(公告)号：EP2302001A1

    公开(公告)日：2011-03-30

    申请号：EP10009436.6

    申请日：2010-09-09

    申请人： Canon Kabushiki Kaisha

    发明人： Takahashi, Kaoru ,  Murai, Yasuaki ,  Inoue, Kei ,  Hirose, Masashi ,  Miyazaki, Takeshi ,  Nagao, Ryosuke ,  Mori, Otome ,  Kawabe, Minako

    IPC分类号： C09B11/20 ,  C09D11/00

    CPC分类号： C09B11/20 ,  C09B11/24 ,  C09D11/328

    摘要： The present invention is a colorant compound represented by the following general formula (1):

    wherein at least one of R 2 , R 4 , R 7 and R 9 is an acylamino group represented by the following general formula (2):

    wherein R 11 denotes one of an alkyl group, a cycloalkyl group, an aryl group, an arylalkyl group, an alkenyl group and a heterocyclic group; and '*' denotes a bonding site with an aromatic ring of the general formula (1).

    摘要翻译： 本发明是由以下通式（1）表示的着色剂化合物：其中R 2，R 4，R 7和R 9中的至少一个是由以下通式（2）表示的酰氨基：其中R 11 表示烷基，环烷基，芳基，芳烷基，烯基和杂环基中的一个; 和'*'表示具有通式（1）的芳环的键合位置。

    Probe for auditory hair cells.
    6.
    发明公开
    Probe for auditory hair cells. 审中-公开
    SarsfürHaarsinneszellen

    公开(公告)号：EP2428230A1

    公开(公告)日：2012-03-14

    申请号：EP11008027.2

    申请日：2009-12-22

    申请人： Canon Kabushiki Kaisha

    发明人： Nomoto, Tsuyoshi ,  Miyazaki, Takeshi ,  Watanabe, Kohei ,  Shintou, Taichi ,  Takahashi, Kaoru ,  Tanaka, Toshio ,  Nishimura, Yuhei ,  Shimada, Yasuhito ,  Nishimura, Norihiro

    IPC分类号： A61K49/00 ,  G01N33/533

    CPC分类号： G01N33/5005 ,  A61K49/0032 ,  A61K49/0041 ,  A61K49/006 ,  C09B11/24 ,  C09B23/0016 ,  C09B23/0058 ,  C09B23/0066 ,  C09B23/0075 ,  C09B23/06 ,  C09B23/105 ,  C09B23/107 ,  G01N33/5044 ,  G01N33/6893 ,  G01N2800/14 ,  G01N2800/20

    摘要： A probe for a hair cell comprises, as an active agent, at least one kind selected from staining compounds represented by the general formula (II):

    where R 11 and R 12 each independently represent one of a carboxylic acid group, a carboxylic acid ester group, a carboxylic acid amide group, a sulfonic acid group, a sulfonic acid ester group, a sulfonic acid amide group, a carboxylic acid salt, and a sulfonic acid salt; R 13 and R 14 each independently represent one of a hydrogen atom, an alkyl group, and an aryl group, and R 15 , R 16 , R 17A , and R 17B each independently represent one of a hydrogen atom, an alkyl group, an aryl group, and a heterocyclic group; and X 2 - represents an anionic group. The staining compound fluoresces in a near-infrared area. The probe is used as a probe for a hair cell, such as for evaluating auditory toxicity of a chemical substance, for screening and/or evaluating a therapeutic drug and a preventive drug for hearing loss.

    摘要翻译： 毛细胞的探针包含选自由通式（II）表示的染色化合物中的至少一种作为活性剂：其中R 11和R 12各自独立地表示羧酸基，羧酸酯 基团，羧酸酰胺基，磺酸基，磺酸酯基，磺酸酰胺基，羧酸盐和磺酸盐; R 13和R 14各自独立地表示氢原子，烷基和芳基中的一个，R 15，R 16，R 17A和R 17B各自独立地表示氢原子，烷基， 芳基和杂环基; X 2 - 表示阴离子基团。 染色化合物在近红外区域发荧光。 该探针用作毛细胞的探针，例如用于评估化学物质的听觉毒性，用于筛选和/或评价治疗药物和用于听力损失的预防药物。