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1.发明公开Sept4/ARTS AS A TUMOR SUPPRESSOR IN THE DIAGNOSIS, PROGNOSIS AND TREATMENT OF HEPATIC DISORDERS 审中-公开9月4日/ ARTS作为肿瘤抑制剂在肝脏疾病的诊断，预后和治疗中的应用
公开(公告)号：EP2983693A1
公开(公告)日：2016-02-17
申请号：EP14782569.9
申请日：2014-04-07
发明人： LARISCH, Sarit , STELLER, Hermann
IPC分类号： A61K38/17 , A61P1/16 , A61P35/00 , C12Q1/68 , G01N33/574
CPC分类号： C12Q1/6886 , A61K31/185 , A61K31/53 , A61K38/17 , C12Q2600/118 , C12Q2600/154 , G01N33/57438 , G01N33/576 , G01N2800/08 , G01N2800/085 , G01N2800/52 , G01N2800/54
摘要： The invention relates to methods for the diagnosis and prognosis of hepatic disorder and associated pathologies as well as of a solid proliferative disorder in a mammalian subject. More specifically, the methods of the invention are based on determining the expression, methylation of ARTS as well as histone trimethylation. The invention further provides therapeutic methods for treating said disorders.
摘要翻译： 本发明涉及用于诊断和预测哺乳动物受试者中肝病和相关病理以及固体增殖性病症的方法。 更具体地说，本发明的方法基于确定表达，ARTS的甲基化以及组蛋白三甲基化。 本发明还提供了治疗所述疾病的治疗方法。
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公开(公告)号：EP3371173A1
公开(公告)日：2018-09-12
申请号：EP16861726.4
申请日：2016-11-02
发明人： LARISCH, Sarit , BARKAN, Dalit
IPC分类号： C07D403/12 , A61K31/496 , A61P35/00
CPC分类号： C07D209/42 , A61K31/496 , A61K45/06 , A61P35/00 , C07D217/02 , C07D231/14
摘要： Provided are ARTS mimetic compounds that act as novel antagonists for XIAP and Bcl-2. Further, the novel ARTS mimetic compounds of the presently claimed subject matter induce apoptosis and/or differentiation in premalignant and malignant cells and thereby restore their normal-like phenotype. Further provided are compositions, methods and uses of said ARTS mimetic compounds in the treatment of cancer and premalignant conditions.
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4.发明公开ANTAGONISTS OF Bcl-2 AND USES THEREOF IN INDUCTION OF APOPTOSIS 审中-公开ANVONISTEN VON BCL-2 UND VERWENDUNGEN DAVON BEI DER INDUKTION EINER APOPTOSE
公开(公告)号：EP2814839A1
公开(公告)日：2014-12-24
申请号：EP13749592.5
申请日：2013-02-14
发明人： LARISCH, Sarit
CPC分类号： C07K14/4747 , A61K38/00 , G01N33/68 , G01N33/6893 , G01N2333/4704 , G01N2510/00 , G01N2800/52
摘要： The present invention provides an antagonist of a Bcl-2 prosurvival protein containing a BH3-like domain. The antagonist of the invention comprises ARTS and any fragment or peptide that comprises a BH3-like domain. The invention further provides compositions, combined compositions and kits as well as methods for treating Bcl-2 over-expressing disorders.
摘要翻译： 本发明提供了含有BH3样结构域的Bcl-2前驱蛋白的拮抗剂。 本发明的拮抗剂包含ARTS和包含BH3样结构域的任何片段或肽。 本发明还提供组合物，组合组合物和试剂盒以及用于治疗Bcl-2过度表达障碍的方法。
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