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1.发明授权
公开(公告)号：EP1019088B1
公开(公告)日：2003-02-12
申请号：EP98949758.1
申请日：1998-10-02
发明人： CARY, Douglas, D.
IPC分类号： A61K31/135 , A61P25/34
CPC分类号： A61K31/135 , A61K45/06 , Y10S514/811 , Y10S514/812 , Y10S514/813 , A61K31/13 , A61K2300/00
摘要： The present invention encompasses methods of treating patients for tobacco addiction and nicotine addiction, for palliating the effects of nicotine withdrawal, for providing or facilitating the effects of smoking cessation therapies and as long-term smoking cessation maintenance therapy. The invention also includes related pharmaceutical compositions comprising nicotine receptor antagonists and either an anti-depressant or an anti-anxiety drug. Specific combinations of drugs (mecamylamine HC1 and bupropion HC1) as well as mecamylamine in combination with certain drug classes (e.g., anti-anxiety drugs and anti-depressants) comprise the pharmaceutical compositions disclosed. These compositions are also contemplated for use in the treatment of cocaine addiction and the treatment of alcohol dependence.
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2.发明公开COMPOSITION FOR THE TREATMENT OF NICOTINE ADDICTION CONTAINING A NICOTINE RECEPTOR ANTAGONIST AND AN ANTI-DEPRESSANT OR ANTI-ANXIETY DRUG 有权组合物治疗尼古丁依赖含烟碱受体拮抗剂和与反抑郁或抗焦虑作用的药物
公开(公告)号：EP1019088A1
公开(公告)日：2000-07-19
申请号：EP98949758.1
申请日：1998-10-02
发明人： CARY, Douglas, D.
IPC分类号： A61K45/06
CPC分类号： A61K31/135 , A61K45/06 , Y10S514/811 , Y10S514/812 , Y10S514/813 , A61K31/13 , A61K2300/00
摘要： The present invention encompasses methods of treating patients for tobacco addiction and nicotine addiction, for palliating the effects of nicotine withdrawal, for providing or facilitating the effects of smoking cessation therapies and as long-term smoking cessation maintenance therapy. The invention also includes related pharmaceutical compositions comprising nicotine receptor antagonists and either an anti-depressant or an anti-anxiety drug. Specific combinations of drugs (mecamylamine HC1 and bupropion HC1) as well as mecamylamine in combination with certain drug classes (e.g., anti-anxiety drugs and anti-depressants) comprise the pharmaceutical compositions disclosed. These compositions are also contemplated for use in the treatment of cocaine addiction and the treatment of alcohol dependence.
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