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公开(公告)号：EP3592343A1
公开(公告)日：2020-01-15
申请号：EP18764856.3
申请日：2018-03-12
IPC分类号： A61K31/33 , A61K31/4523 , A61K35/76 , A61K39/125 , C12N7/00
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公开(公告)号：EP3487527A1
公开(公告)日：2019-05-29
申请号：EP17831976.0
申请日：2017-07-21
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公开(公告)号：EP3215520A1
公开(公告)日：2017-09-13
申请号：EP15857504.3
申请日：2015-11-09
IPC分类号： C07K14/005 , C12N15/86 , C07H17/02
CPC分类号： A61K39/12 , A61K31/704 , A61K2039/5258 , A61K2039/544 , A61K2039/585 , A61P35/00 , A61P35/04 , C12N7/00 , C12N2770/00023 , C12N2770/00034 , C12N2770/00071 , C12N2770/32022 , C12N2770/32023 , C12N2770/32034 , C12N2770/32071
摘要： A method of treating cancer in a subject in need thereof includes administering in situ to the cancer a therapeutically effective amount of a virus or virus-like particle.
摘要翻译： 描述了在有需要的受试者中治疗癌症的方法，其包括向受试者施用治疗有效量的病毒或病毒样颗粒，其中所述病毒颗粒在受试者中不复制且不感染。 该方法代表了一种原位疫苗接种，其中将免疫刺激试剂直接应用于肿瘤改变肿瘤微环境，使得免疫系统能够对肿瘤作出反应。
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公开(公告)号：EP3957644A1
公开(公告)日：2022-02-23
申请号：EP21201960.8
申请日：2015-11-09
IPC分类号： C07K14/005 , C12N15/86 , C07H17/02
摘要： A method of treating cancer in a subject in need thereof is described that includes administering a therapeutically effective amount of a virus or virus-like particle to the subject, wherein the virus particle is nonreplicating and noninfectious in the subject. The method represents a type of in situ vaccination, in which application of an immunostimulatory reagent directly to the tumor modifies the tumor microenvironment so that the immune system is able to respond to the tumor.
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公开(公告)号：EP3322485A1
公开(公告)日：2018-05-23
申请号：EP16825306.0
申请日：2016-07-18
CPC分类号： A61K47/6901 , A61K31/401 , A61K39/12 , A61K47/646 , A61K47/65 , A61K47/6811 , A61P35/00 , C07K5/06052
摘要： Anti-lymphoma plant virus particles are described. The anti-lymphoma plant virus particles include a filamentous or rod-shaped plant virus particle linked to an antimitotic agent. A therapeutically effective amount of an anti-lymphoma plant virus particle can be administered to a subject to provide a method of treating lymphoma.
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公开(公告)号：EP3725332A1
公开(公告)日：2020-10-21
申请号：EP20179136.5
申请日：2016-07-18
摘要： Anti-lymphoma plant virus particles are described. The anti-lymphoma plant virus particles include a filamentous or rod-shaped plant virus particle linked to an antimitotic agent. A therapeutically effective amount of an anti-lymphoma plant virus particle can be administered to a subject to provide a method of treating lymphoma.
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公开(公告)号：EP3535283A1
公开(公告)日：2019-09-11
申请号：EP17868454.4
申请日：2017-11-03
IPC分类号： C07K14/005 , A61K9/51 , A61K9/52 , B82Y5/00
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公开(公告)号：EP3313527A1
公开(公告)日：2018-05-02
申请号：EP16818636.9
申请日：2016-06-29
CPC分类号： A61K31/555 , A61K9/0019 , A61K9/5184 , A61K39/12 , A61K47/6901 , C12N2750/12022 , C12N2750/12023 , C12N2770/32022 , C12N2770/32023
摘要： Anticancer virus particles are described. Anticancer virus particles are filamentous or rod-shaped plant virus particle containing an anticancer agent within the interior of the virus particle. The anticancer agent can be attached either covalently or non-covalently within the interior of the virus particle. A therapeutically effective amount of an anticancer virus particle can be administered to a subject identified as having cancer to provide a method of cancer treatment.
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