专利检索 ap:("Celgene Corporation" OR "NATIONAL UNIVERSITY CORPORATION OITA UNIVERSITY") AND inv:"IHA, Hidekatsu" 第 1 页

1.

发明公开
METHODS FOR DETERMINING DRUG EFFICACY FOR TREATMENT OF CANCER USING RATIOS OF CEREBLON ASSOCIATED PROTEINS 审中-公开
标题翻译：利用脑蛋白相关蛋白比率确定药物治疗癌症的方法

公开(公告)号：EP3304076A1

公开(公告)日：2018-04-11

申请号：EP16804297.6

申请日：2016-06-01

申请人： Celgene Corporation , NATIONAL UNIVERSITY CORPORATION OITA UNIVERSITY

发明人： IHA, Hidekatsu , IKEBE, Emi

IPC分类号： G01N33/50 , G01N21/75 , A61K31/454

CPC分类号： G01N33/57484 , A61K31/454 , C12Q1/6886 , C12Q2600/106 , C12Q2600/158 , G01N33/57426 , G01N2333/47

摘要： A method of identifying a subject having cancer who is likely to be responsive to a treatment compound, comprising administering a treatment compound to a subject having cancer; obtaining a sample from the subject; determining the ratio of a first biomarker level to a second biomarker level in the sample from the subject, wherein at least one of the biomarkers is a CRBN-associated protein; and diagnosing the subject as being likely to be responsive to the treatment compound if the ratio of the biomarker levels in the sample of the subject changes as compared to a reference ratio of the biomarker levels.