公开(公告)号：EP1218514B1

公开(公告)日：2006-04-26

申请号：EP00964541.7

申请日：2000-10-06

申请人： Celltech Pharma Europe Limited

发明人： JONES, C. Elan Corp. ,  BACON, A. Lipoxen Technologies Limited ,  DOUCE, G. Divisin of Infection & Immunity, IBLS ,  PAGE, M. Apovia AG

IPC分类号： C12N15/36 ,  C07K14/02 ,  A61K39/12 ,  A61P37/02 ,  C12N15/62

CPC分类号： C07K14/005 ,  A61K38/00 ,  A61K2039/55555 ,  A61K2039/57 ,  C07K2319/00 ,  C12N2730/10122 ,  C12N2740/16122

摘要： The invention provides a method for designing protein immunogen, which comprises (a) modifying the amino acid sequence of the immunogen, and (b) determining whether the T-helper (Th) cell response to the modified immunogen is of the Th1 type or the Th2 type. The method is useful in identifying immunogens for use in immunotherapy of diseases. For example, chronic hepatitis is believed to be associated with a Th2-dominated response which fails to clear the virus, and switching the Th response to a Th1 response by administration of an immunogen that induces a Th1 response may help in clearing the virus.