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1.发明公开
公开(公告)号：EP4340887A1
公开(公告)日：2024-03-27
申请号：EP22733859.7
申请日：2022-05-18
申请人： Centre National de la Recherche Scientifique , Université de Montpellier , INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE - INSERM , Ecole Nationale Supérieure de Chimie de Montpellier
发明人： PASCUSSI, Jean-Marc , PANNEQUIN, Julie , AMBLARD-CAUSSIL, Muriel , LACONDE, Guillaume , GERBAL-CHALOIN, Sabine , CHAVANIEU, Alain , BOURGUET, William , DELFOSSE, Vanessa
IPC分类号： A61K47/55 , A61K47/54 , C07D401/12 , C07D401/14 , A61P35/00
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公开(公告)号：EP3296319A1
公开(公告)日：2018-03-21
申请号：EP17197865.3
申请日：2011-01-07
申请人： Centre National de la Recherche Scientifique (CNRS) , INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE (INSERM) , Progastrine et Cancers S.à r.l.
发明人： PANNEQUIN, Julie , HOUHOU, Leila , FRAMERY, Berenice , ERKILIC, Nejla , JOUBERT, Dominique , HOLLANDE, Frederic
IPC分类号： C07K16/26 , A61K39/395 , A61P35/00
CPC分类号： C07K16/26 , A61K39/39558 , A61K2039/505 , C07K5/1016 , C07K16/3046 , C07K2317/24 , C07K2317/73 , C07K2317/76 , G01N33/57419 , G01N2333/595 , G01N2800/52
摘要： The present disclosure is directed to methods of treating and preventing colorectal cancer metastasis or recurrence of colorectal cancer with compositions comprising anti-progastrin antibodies.
摘要翻译： 本公开涉及用包含抗前胃泌素抗体的组合物治疗和预防结肠直肠癌转移或结直肠癌复发的方法。
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公开(公告)号：EP3421493A1
公开(公告)日：2019-01-02
申请号：EP18185172.6
申请日：2010-10-15
申请人： Progastrine et Cancers S.à r.l. , CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (CNRS) , INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE (INSERM)
IPC分类号： C07K16/26 , A61K39/395 , A61P35/00
摘要： The present disclosure is directed to progastrin monoclonal antibodies, fragments thereof, compositions comprising progastrin monoclonal antibodies, and methods of making and using progastrin monoclonal antibodies and compositions thereof. The present disclosure is directed to methods of treating colorectal cancer with progastrin monoclonal antibodies and compositions comprising progastrin monoclonal antibodies or fragments thereof. The present disclosure is further directed to methods comprising detection of progastrin, including methods of diagnosing colorectal cancer and methods of monitoring efficacy of anti-cancer therapy in subjects suffering from colorectal cancer.
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公开(公告)号：EP2040753A2
公开(公告)日：2009-04-01
申请号：EP07734620.3
申请日：2007-05-21
申请人： INSERM (Institut National de la Santé et de la Recherche Médicale) , CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (CNRS) , Université de Montpellier I
发明人： HOLLANDE, Frédéric , JOUBERT, Dominique , JAY, Philippe , PANNEQUIN, Julie , DELAUNAY, Nathalie , BOURGAUX, Jean-François
CPC分类号： C07K16/26 , C07K2317/34 , C07K2317/76 , C12N15/1135 , C12N15/1136 , C12N2310/111 , C12N2310/14
摘要： The present invention relates to inhibitors of progastrin induced repression of ICAT for treating and/or preventing colorectal cancer, adenomatous polyposis or metastasis displaying progastrin-secreting cells and cells in which the beta-catenin/Tcf-4-mediated transcriptional pathway is constitutively active.
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公开(公告)号：EP2040753B8
公开(公告)日：2019-04-10
申请号：EP07734620.3
申请日：2007-05-21
申请人： INSERM (Institut National de la Santé et de la Recherche Médicale) , CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE -CNRS- , Université de Montpellier
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公开(公告)号：EP2040753B1
公开(公告)日：2019-02-27
申请号：EP07734620.3
申请日：2007-05-21
申请人： INSERM (Institut National de la Santé et de la Recherche Médicale) , CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE -CNRS- , Université de Montpellier
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公开(公告)号：EP2542585A2
公开(公告)日：2013-01-09
申请号：EP11704178.0
申请日：2011-01-07
申请人： Bioréalités , INSERM - Institut National de la Santé et de la Recherche Médicale , Centre National de la Recherche Scientifique CNRS
发明人： PANNEQUIN, Julie , HOUHOU, Leïla , FRAMERY, Bérénice , ERKILIC, Nejla , JOUBERT, Dominique , HOLLANDE, Frédéric
IPC分类号： C07K16/26
CPC分类号： C07K16/26 , A61K39/39558 , A61K2039/505 , C07K5/1016 , C07K16/3046 , C07K2317/24 , C07K2317/73 , C07K2317/76 , G01N33/57419 , G01N2333/595 , G01N2800/52
摘要： The present disclosure is directed to methods of treating and preventing colorectal cancer metastasis or recurrence of colorectal cancer with compositions comprising anti-progastrin antibodies.
摘要翻译： 本公开涉及用包含抗前泌肽抗体的组合物治疗和预防结肠直肠癌转移或结肠直肠癌复发的方法。
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公开(公告)号：EP2488551B1
公开(公告)日：2018-07-25
申请号：EP10768878.0
申请日：2010-10-15
申请人： Progastrine et Cancers S.à r.l. , Institut National de la Santé et de la Recherche Médicale (INSERM) , Centre National de la Recherche Scientifique (C.N.R.S.)
IPC分类号： C07K16/26
CPC分类号： C07K16/26 , A61K2039/505 , C07K2317/24 , C07K2317/33 , C07K2317/34 , C07K2317/565 , C07K2317/567 , C07K2317/73 , C07K2317/76 , C07K2317/92 , G01N33/57419 , G01N33/57488 , G01N2333/595
摘要： The present disclosure is directed to progastrin monoclonal antibodies, fragments thereof, compositions comprising progastrin monoclonal antibodies, and methods of making and using progastrin monoclonal antibodies and compositions thereof. The present disclosure is directed to methods of treating colorectal cancer with progastrin monoclonal antibodies and compositions comprising progastrin monoclonal antibodies or fragments thereof. The present disclosure is further directed to methods comprising detection of progastrin, including methods of diagnosing colorectal cancer and methods of monitoring efficacy of anti-cancer therapy in subjects suffering from colorectal cancer.
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公开(公告)号：EP2542585B8
公开(公告)日：2017-12-13
申请号：EP11704178.0
申请日：2011-01-07
申请人： Progastrine et Cancers S.à r.l. , Institut National de la Santé et de la Recherche Médicale (INSERM) , Centre National de la Recherche Scientifique (CNRS)
发明人： PANNEQUIN, Julie , HOUHOU, Leïla , FRAMERY, Bérénice , ERKILIC, Nejla , JOUBERT, Dominique , HOLLANDE, Frédéric
IPC分类号： C07K16/26
CPC分类号： C07K16/26 , A61K39/39558 , A61K2039/505 , C07K5/1016 , C07K16/3046 , C07K2317/24 , C07K2317/73 , C07K2317/76 , G01N33/57419 , G01N2333/595 , G01N2800/52
摘要： The present disclosure is directed to methods of treating and preventing colorectal cancer metastasis or recurrence of colorectal cancer with compositions comprising anti-progastrin antibodies.
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公开(公告)号：EP2542585B1
公开(公告)日：2017-10-25
申请号：EP11704178.0
申请日：2011-01-07
申请人： Les Laboratoires Servier , Institut National de la Santé et de la Recherche Médicale (INSERM) , Centre National de la Recherche Scientifique (CNRS)
发明人： PANNEQUIN, Julie , HOUHOU, Leïla , FRAMERY, Bérénice , ERKILIC, Nejla , JOUBERT, Dominique , HOLLANDE, Frédéric
IPC分类号： C07K16/26
CPC分类号： C07K16/26 , A61K39/39558 , A61K2039/505 , C07K5/1016 , C07K16/3046 , C07K2317/24 , C07K2317/73 , C07K2317/76 , G01N33/57419 , G01N2333/595 , G01N2800/52
摘要： The present disclosure is directed to methods of treating and preventing colorectal cancer metastasis or recurrence of colorectal cancer with compositions comprising anti-progastrin antibodies.
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