公开(公告)号：EP2313373A1

公开(公告)日：2011-04-27

申请号：EP09780818.2

申请日：2009-07-20

申请人： Centre National de la Recherche Scientifique (C.N.R.S)

发明人： SCHMIDT, Fanny ,  FIGADERE, Bruno ,  VOZARI, Rita, Sylvia ,  CHAMPY, Pierre, ,  FRANCK, Xavier

IPC分类号： C07D215/14 ,  C07D241/44 ,  A61K31/395 ,  A61K31/495 ,  A61P25/16 ,  A61P25/28

CPC分类号： C07D215/14 ,  C07D241/44

摘要： The present invention relates to compounds of Formula (I) below, to their pharmaceutically acceptable salts and to their isomers or mixtures of isomers: HetAr−X−CHR
1 R
2 (I) in which: - HetAr represents a group chosen from: - X represents a linear, saturated or unsaturated, hydrocarbon-based chain comprising from 8 to 22 carbon atoms, optionally interrupted by an –NH- or –NH-CO- group, - R
1 represents a hydrogen atom or an –OH, -O(C
1 -C
6 )alkyl, -OCO((C
1 -C
6 )alkyl), -OSO
2 ((C
1 -C
6 )alkyl) or –OSO
3 H group, and - R
2 represents a hydrogen atom or a (C
2 -C
6 )alkynyl, (C
2 ‑C
6 )alkenyl or (C
3 -C
6 )cycloalkyl group. The present invention also relates to a process for preparing the compounds of Formula (I), and also to the use thereof, especially in the treatment of neurodegenerative diseases.