专利检索 ap:("Centre National de la Recherche Scientifique - CNRS" OR "UNIVERSITE PARIS DESCARTES" OR "INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE (INSERM)" OR "Ecole Nationale Superieure de Chimie de Paris") AND inv:"MARTIN, Brice, René Jules" 第 1 页

1.

发明公开
PREPARATION OF NANOSUSPENSION COMPRISING NANOCRYSTALS OF ACTIVE PHARMACEUTICAL INGREDIENTS WITH LITTLE OR NO STABILIZING AGENTS 审中-公开

公开(公告)号：EP3616688A1

公开(公告)日：2020-03-04

申请号：EP18306138.1

申请日：2018-08-27

申请人： Centre National de la Recherche Scientifique - CNRS , UNIVERSITE PARIS DESCARTES , INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE (INSERM) , Ecole Nationale Superieure de Chimie de Paris

发明人： MARTIN, Brice, René Jules , MIGNET, Nathalie , CORVIS, Yohann

IPC分类号： A61K9/14 , A61K9/51 , A61K31/365 , A61K31/7048 , A61P35/00

摘要： The invention relates to a method for manufacturing a nanostructured powder comprising nanocrystalline agglomerates containing active pharmaceutical ingredient (API) in its crystalline form, said method comprising (i) Preparing a first solution comprising API and an API solvent; (ii) Mixing the first solution with a second solution comprising an API antisolvent and optionally a stabilizing agent P1 to obtain a third mixture; (iii) Evaporating the third mixture until both the API solvent and the API antisolvent are evaporated, advantageously under vacuum; characterized in that when the stabilizing agent P1 is present, the third mixture has a stabilizing agent P1 to API weight ratio equal or less than 5, preferably less than 2. The invention also concerns a nanostructured powder and a nanosuspension.