公开(公告)号：EP4321181A1

公开(公告)日：2024-02-14

申请号：EP22306206.8

申请日：2022-08-10

申请人： Centre national de la recherche scientifique ,  École Normale Supérieure ,  Ecole Supérieure de Physique et de Chimie Industrielles de la Ville de Paris ,  Instituto Superior Técnico ,  Faculdade De Ciências da Universidade de Lisboa

发明人： SERRE, Christian ,  TISSOT, Antoine ,  CAO, Chenchen ,  LUZIA GONCALVES PINTO, Moisés ,  SILVA, João ,  ANTUNES, Fernando ,  PINTO, Rosana

IPC分类号： A61L15/00 ,  A61P17/02 ,  A61P31/00 ,  B01D53/00 ,  B01D53/94 ,  C07F9/38 ,  C07F15/02

摘要： The present invention belongs to the field of nanoporous materials, in particular metal organic frameworks (MOFs) and Lewis-based gas delivery and/or slow release, or the detection of Lewis-based gas(es) in gases or liquid streams.
The present invention relates, inter alia, to a new ultra-microporous crystalline metal organic framework solid ( comprising bisphosphonic acid ligands (also refered to as Phosphonate MOF), such as MIP-210(M) and uses thereof as a carrier in Lewis-based gas (such as NO) delivery. The invention also relates to controlled release of the Lewis-based gas in wounds, for example by topical application. The invention also encompasses a synthetic method for producing the new ultra-microporous crystalline metal organic framework solid of the invention.
The MOFs of the present invention can be used in various applications such as gas carrier and/or for the controlled release of gas. The MOFs of the present invention thus are very versatile and have therapeutic and non therapeutic applications.