公开(公告)号：EP3733196A1

公开(公告)日：2020-11-04

申请号：EP18845399.7

申请日：2018-12-21

申请人： Centro De Ingenieria Genetica Y Biotecnologia

发明人： DOMÍNGUEZ HORTA, María del Carmen ,  LOPEZ ABAD, Cruz Matilde ,  GONZÁLEZ LÓPEZ, Luis Javier ,  BESADA PÉREZ, Vladimir Armando

IPC分类号： A61K38/17 ,  C07K14/47 ,  A61P29/00

摘要： The invention is relate with a pharmaceutical composition comprising peptide type APL called identified as SEQ ID No. 1, sodium acetate buffer at pH 3.9 - 4.7; and at least one stabilizing sugar selected from sucrose or trehalose. This pharmaceutical composition is useful for manufacture of a medicament for treating inflammatory diseases related to an increase of neutrophils or citrullination of proteins. These inflammatory diseases include rheumatoid arthritis (RA), juvenile idiopathic arthritis (JIA), ankylosing spondylitis (AS), Alzheimer's disease, and hepatic and pulmonary fibrosis. The invention also discloses a method for the treatment of these diseases, through effective therapeutic administration of the pharmaceutical composition of APL-type peptide.