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1.发明公开FUSED BICYCLIC DERIVATIVES OF 2,4-DIAMINOPYRIMIDINE AS ALK AND C-MET INHIBITORS 有权AS ALK和c-Met抑制剂的2,4-二氨基嘧啶稠合双环衍生物
公开(公告)号：EP2222647A1
公开(公告)日：2010-09-01
申请号：EP07861484.9
申请日：2007-10-23
申请人： Cephalon, Inc.
发明人： AHMED, Gulzar , BOHNSTEDT, Adolph , BRESLIN, Henry, Joseph , BURKE, Jason , CURRY, Matthew, A. , DIEBOLD, James, L. , DORSEY, Bruce , DUGAN, Benjamin, J. , FENG, Daming , GINGRICH, Diane, E. , GUO, Tao , HO, Koc-Kan , LEARN, Keith, S. , LISKO, Joseph, G. , LIU, Rong-Qiang , MESAROS, Eugen, F. , MILKIEWICZ, Karen , OTT, Gregory, R. , PARRISH, Jonathan , THEROFF, Jay, P. , THIEU, Tho, V. , TRIPATHY, Rabindranath , UNDERINER, Theodore, L. , WAGNER, Jason, C. , WEINBERG, Linda , WELLS, Gregory, J. , YOU, Ming , ZIFICSAK, Craig, A.
IPC分类号： C07D239/48 , C07D403/12 , C07D403/14 , C07D405/12 , C07D405/14 , C07D413/12 , C07D417/12 , C07D417/14 , A61K31/495 , A61P35/00
CPC分类号： C07D239/48 , C07D403/12 , C07D403/14 , C07D405/12 , C07D405/14 , C07D413/12 , C07D417/12 , C07D417/14
摘要： The present invention provides a compound of formula I or II or a pharmaceutically acceptable salt form thereof, wherein R1, R2, R3, R4, R5, A1, A2, A3, A4, and A5, are as defined herein. The compounds of formula I or II have ALK and/or c-Met inhibitory activity, and may be used to treat proliferative disorders.
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2.发明授权FUSED BICYCLIC DERIVATIVES OF 2,4-DIAMINOPYRIMIDINE AS ALK AND C-MET INHIBITORS 有权AS ALK和c-Met抑制剂的2,4-二氨基嘧啶稠合双环衍生物
公开(公告)号：EP2222647B1
公开(公告)日：2015-08-05
申请号：EP07861484.9
申请日：2007-10-23
申请人： Cephalon, Inc.
发明人： AHMED, Gulzar , BOHNSTEDT, Adolph , BRESLIN, Henry, Joseph , BURKE, Jason , CURRY, Matthew, A. , DIEBOLD, James, L. , DORSEY, Bruce , DUGAN, Benjamin, J. , FENG, Daming , GINGRICH, Diane, E. , GUO, Tao , HO, Koc-Kan , LEARN, Keith, S. , LISKO, Joseph, G. , LIU, Rong-Qiang , MESAROS, Eugen, F. , MILKIEWICZ, Karen , OTT, Gregory, R. , PARRISH, Jonathan , THEROFF, Jay, P. , THIEU, Tho, V. , TRIPATHY, Rabindranath , UNDERINER, Theodore, L. , WAGNER, Jason, C. , WEINBERG, Linda , WELLS, Gregory, J. , YOU, Ming , ZIFICSAK, Craig, A.
IPC分类号： C07D239/48 , C07D403/12 , C07D403/14 , C07D405/12 , C07D405/14 , C07D413/12 , C07D417/12 , C07D417/14 , A61K31/495 , A61P35/00
CPC分类号： C07D239/48 , C07D403/12 , C07D403/14 , C07D405/12 , C07D405/14 , C07D413/12 , C07D417/12 , C07D417/14
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