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1.发明公开Fused bicyclic derivatives of 2,4-diaminopyrimidine as alk and C-met inhibitors 有权2,4-二氨基嘧啶的稠合双环衍生物作为ALK和c-Met抑制剂
公开(公告)号：EP2684874A1
公开(公告)日：2014-01-15
申请号：EP13173365.1
申请日：2007-10-23
申请人： Cephalon, Inc.
发明人： Ahmed, Gulzar , Bohnstedt, Adolph , Breslin, Henry, Joseph , Burke, Jason , Curry, Matthew , Diebold, James, L. , Dorsey, Bruce , Dugan, Benjamin, J. , Feng, Daming , Gingrich, Diane, E. , Guo, Tao , Ho, Koc-Kan , Learn, Keith, S. , Lisko, Joseph, G. , Liu, Rong-Qiang , Mesaros, Eugen, F. , Milkiewicz, Karen , Ott, Gregory, R. , Parrish, Jonathan , Theroff, Jay, P. , Thieu, Tho, V. , Tripathy, Rabindranath , Underiner, Theodore, L. , Wagner, Jason, C. , Weinberg, Linda , Wells, Gregory, J. , You, Ming , Zificsak, Craig, A.
IPC分类号： C07D239/48 , C07D403/12 , C07D403/14 , C07D405/12 , C07D405/14 , C07D413/12 , C07D417/12 , C07D417/14 , A61K31/495 , A61P35/00
CPC分类号： C07D239/48 , C07D403/12 , C07D403/14 , C07D405/12 , C07D405/14 , C07D413/12 , C07D417/12 , C07D417/14
摘要： The present invention provides a compound of formula I or II or a pharmaceutically acceptable salt form thereof, wherein R 1 , R 2 , R 3 , R 4 , R 5 , A 1 , A 2 , A 3 , A 4 , and A 5 , are as defined herein. The compounds of formula I or II have ALK and/or c-Met inhibitory activity, and may be used to treat proliferative disorders.
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2.发明授权Fused bicyclic derivatives of 2,4-diaminopyrimidine as alk and C-met inhibitors 有权作为alk和C-met抑制剂的2,4-二氨基嘧啶的稠合二环衍生物
公开(公告)号：EP2684874B1
公开(公告)日：2017-05-17
申请号：EP13173365.1
申请日：2007-10-23
申请人： Cephalon, Inc.
发明人： Ahmed, Gulzar , Bohnstedt, Adolph , Breslin, Henry, Joseph , Burke, Jason , Curry, Matthew , Diebold, James, L. , Dorsey, Bruce , Dugan, Benjamin, J. , Feng, Daming , Gingrich, Diane, E. , Guo, Tao , Ho, Koc-Kan , Learn, Keith, S. , Lisko, Joseph, G. , Liu, Rong-Qiang , Mesaros, Eugen, F. , Milkiewicz, Karen , Ott, Gregory, R. , Parrish, Jonathan , Theroff, Jay, P. , Thieu, Tho, V. , Tripathy, Rabindranath , Underiner, Theodore, L. , Wagner, Jason, C. , Weinberg, Linda , Wells, Gregory, J. , You, Ming , Zificsak, Craig, A.
IPC分类号： C07D239/48 , C07D403/12 , C07D403/14 , C07D405/12 , C07D405/14 , C07D413/12 , C07D417/12 , C07D417/14 , A61K31/495 , A61P35/00
CPC分类号： C07D239/48 , C07D403/12 , C07D403/14 , C07D405/12 , C07D405/14 , C07D413/12 , C07D417/12 , C07D417/14
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