公开(公告)号：EP3272746A1

公开(公告)日：2018-01-24

申请号：EP16767717.8

申请日：2016-03-18

申请人： Chai Tai Tianqing Pharmaceutical Group Co., Ltd. ,  Centaurus BioPharma Co., Ltd. ,  Lianyungang Runzhong Pharmaceutical Co., Ltd.

发明人： ZHANG, Xiquan ,  TANG, Song ,  FENG, Weiwei ,  TIAN, Xin ,  CHEN, Zhilin ,  GU, Hongmei ,  XU, Hongjiang ,  LIU, Fei

IPC分类号： C07D403/12 ,  C07D401/12 ,  C07D405/14 ,  A61K31/517 ,  A61K31/5377 ,  A61P35/00

摘要： The present application relates to maleates of a compound of Formula I, methods for preparing the same, pharmaceutical compositions thereof and uses thereof in the treatment of tumors, such as non-small cell lung cancer, breast cancer, and other malignant tumors.

摘要翻译： 本申请涉及式I化合物的马来酸盐，其制备方法，其药物组合物及其在治疗肿瘤如非小细胞肺癌，乳腺癌和其他恶性肿瘤中的用途。

公开(公告)号：EP3476841A1

公开(公告)日：2019-05-01

申请号：EP17814745.0

申请日：2017-06-23

申请人： Chia Tai Tianqing Pharmaceutical Group Co., Ltd. ,  Lianyungang Runzhong Pharmaceutical Co., Ltd. ,  Centaurus BioPharma Co., Ltd.

发明人： ZHU, Yizhong ,  TANG, Jianqiu ,  LIU, Fei ,  ZHANG, Xiquan ,  GU, Hongmei ,  ZHU, Bo ,  WANG, Lulu ,  TANG, Song ,  ZHANG, Yanyang

IPC分类号： C07D403/04 ,  A61K31/506 ,  A61P35/00 ,  A61P35/02

摘要： The present application belongs to the field of medicinal chemistry, and relates to crystals of an aniline pyrimidine compound serving as an EGFR inhibitor. Specifically, the present application relates to crystal A, crystal B and crystal C of N-(2-((2-(dimethyl amino)ethyl)(methyl)amino)-4-methoxy-5-(4-(3-methyl-2-oxo-2,3-dihydro-1H-benzo[d]imidazole-1-base)pyrimidine-2-base amino)phenyl)acrylamide (formula I) hydrochloride, and also relates to the method for preparing the crystal A, the crystal B and the crystal C, a crystal composition comprising the crystal A, the crystal B, and the crystal C, a pharmaceutical composition comprising the crystal A, the crystal B and the crystal C or the crystal composition thereof, and medical uses thereof. The crystal A, the crystal B and the crystal C in the present application has the advantages of high purity, high crystallization degree, good stability and the like.

公开(公告)号：EP3272746B1

公开(公告)日：2019-12-25

申请号：EP16767717.8

申请日：2016-03-18

申请人： Chia Tai Tianqing Pharmaceutical Group Co., Ltd. ,  Centaurus BioPharma Co., Ltd. ,  Lianyungang Runzhong Pharmaceutical Co., Ltd.

发明人： ZHANG, Xiquan ,  TANG, Song ,  FENG, Weiwei ,  TIAN, Xin ,  CHEN, Zhilin ,  GU, Hongmei ,  XU, Hongjiang ,  LIU, Fei

IPC分类号： C07D403/12 ,  C07D401/12 ,  C07D405/14 ,  A61K31/517 ,  A61K31/5377 ,  A61P35/00 ,  A61K31/4427 ,  A61K45/06 ,  C07D239/94 ,  C07D211/40