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1.发明公开Use of an Ang-(1-7) receptor agonist in acute lung injury 有权Verwendung eines Ang-（1-7）-Rezeptorantagonisten bei akuter Lungenverletzung
公开(公告)号：EP2163259A1
公开(公告)日：2010-03-17
申请号：EP08016142.5
申请日：2008-09-12
发明人： Walther, Thomas , Kübler, Wolfgang
CPC分类号： A61K38/085 , A61K31/4178 , C07D409/10 , C07K7/14
摘要： The present invention refers to a peptidic or non-peptidic angiotensin-(1-7) (Ang-(1-7)) receptor agonist, preferably a Mas receptor agonist, for the prevention and/or treatment of acute lung injury, preferably acute respiratory distress syndrome.
摘要翻译： 本发明涉及用于预防和/或治疗急性肺损伤的肽或非肽血管紧张素（1-7）（Ang-（1-7））受体激动剂，优选Mas受体激动剂，优选急性 呼吸窘迫综合征。
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公开(公告)号：EP4173626A1
公开(公告)日：2023-05-03
申请号：EP21205486.0
申请日：2021-10-29
IPC分类号： A61K31/7024 , A61P9/10 , A61P11/00
摘要： The present invention is directed to pentagalloyl glucose (PGG), a pharmaceutically acceptable salt thereof or a pharmaceutical composition comprising the same for use in treatment or prevention of pulmonary hypertension, preferably of pulmonary hypertension secondary to left heart disease.
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公开(公告)号：EP4245302A1
公开(公告)日：2023-09-20
申请号：EP22162072.7
申请日：2022-03-15
IPC分类号： A61K31/404 , A61K31/443 , A61K31/47 , A61P7/02 , A61K31/4439
摘要： The invention relates to the field of pharmaceutical compositions and the treatment and/or prevention of medical conditions comprising thrombosis, or atherosclerosis associated with pathological thrombocyte activation. The invention further relates to a cystic fibrosis transmembrane conductance regulator (CFTR) modulator for use in the treatment and/or prevention of a medical condition comprising thrombosis, or a medical condition comprising atherosclerosis and pathological thrombocyte activation, in a human subject. The invention further relates to the medical use and corresponding therapeutic methods of administering a CFTR modulator, such as ivacaftor, in the treatment and/or prevention of a medical condition pathological thrombocyte activation, adhesion and/or aggregation. In further aspects, the invention relates to a pharmaceutical composition comprising a CFTR modulator, such as ivacaftor.
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公开(公告)号：EP4218772A1
公开(公告)日：2023-08-02
申请号：EP22153401.9
申请日：2022-01-26
发明人： Kübler, Wolfgang , Solymosi, Philip
摘要： The present invention is directed to lithium salt or a pharmaceutical composition comprising the same for use in treatment or prevention of pulmonary hypertension.
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公开(公告)号：EP2163259B1
公开(公告)日：2012-06-13
申请号：EP08016142.5
申请日：2008-09-12
发明人： Walther, Thomas , Kübler, Wolfgang
IPC分类号： A61K31/4178 , A61K38/08 , A61P11/00
CPC分类号： A61K38/085 , A61K31/4178 , C07D409/10 , C07K7/14
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