公开(公告)号：EP3915589A1

公开(公告)日：2021-12-01

申请号：EP20177188.8

申请日：2020-05-28

申请人： Charité - Universitätsmedizin Berlin

发明人： HAMM, Bernd ,  SCHELLENBERGER, Eyk ,  SCHNORR, Jörg ,  HAUPTMANN, Ralf ,  HÄCKEL, Akvile ,  XIE, Jing

IPC分类号： A61K49/10 ,  C07C229/16 ,  C07C237/04

摘要： The present disclosure provides novel Fe(III)-complexes according to Chemical Formula (I):

as well as enantiomers (and diastereomers) and solvates thereof. In Chemical Formula (I), Z is selected from O, NH and NR, wherein R is a branched or linear C1-C15 alkyl. R 1 is C1-C15 alkyl. Further, the orientation of the amine groups of the cyclohexyl ring in Chemical Formula (I) defines a trans-isomer. A further aspect of the disclosure refers to a contrast agent for magnet resonance imaging, which includes the Fe(III)-complex according to the present disclosure. In addition, the present disclosure provides novel ligands according to Chemical Formula (II), as well as (diastereomers and) enantiomers thereof, which constitute intermediate products for preparation of prespecified Fe(III)-complexes.

公开(公告)号：EP3813887A1

公开(公告)日：2021-05-05

申请号：EP19728077.9

申请日：2019-06-06

申请人： Charité - Universitätsmedizin Berlin

发明人： SCHELLENBERGER, Eyk ,  HAUPTMANN, Ralf ,  HÄCKEL, Akvile ,  XIE, Jing ,  SCHNORR, Jörg ,  HAMM, Bernd

IPC分类号： A61K49/10

公开(公告)号：EP4157360A1

公开(公告)日：2023-04-05

申请号：EP21728216.9

申请日：2021-05-25

申请人： Charité - Universitätsmedizin Berlin

发明人： HAMM, Bernd ,  SCHELLENBERGER, Eyk ,  SCHNORR, Jörg ,  HAUPTMANN, Ralf ,  HÄCKEL, Akvile ,  XIE, Jing

IPC分类号： A61K49/10 ,  C07C229/16 ,  C07C237/04

公开(公告)号：EP2187976A2

公开(公告)日：2010-05-26

申请号：EP08785433.7

申请日：2008-08-07

申请人： Charité - Universitätsmedizin Berlin

发明人： SCHELLENBERGER, Eyk ,  WAGNER, Susanne ,  SCHNORR, Jörg

IPC分类号： A61K49/18

CPC分类号： A61K49/1866 ,  A61K49/1857 ,  B82Y5/00

摘要： The present invention relates to the production of marker particles, which are especially useful for target-specific molecular magnetic resonance imaging (MRI), using charged iron oxide nanoparticles and inversely charged peptides covalently linked to macromolecules, which are capable of binding to a specific type of cells.

公开(公告)号：EP4045095A1

公开(公告)日：2022-08-24

申请号：EP20789431.2

申请日：2020-10-16

申请人： Charité - Universitätsmedizin Berlin

发明人： SCHELLENBERGER, Eyk ,  HAUPTMANN, Ralf ,  HÄCKEL, Akvile ,  XIE, Jing ,  SCHNORR, Jörg ,  HAMM, Bernd

IPC分类号： A61K49/10 ,  C07C229/10