公开(公告)号：EP3164412A1

公开(公告)日：2017-05-10

申请号：EP15815035.9

申请日：2015-07-01

申请人： Cheer Global Ltd.

发明人： WONG, Bing Lou ,  WAI, Norman Fung Man ,  KWOK, Sui Yi

IPC分类号： C07K14/805 ,  A61K38/42 ,  A61K31/505 ,  A61K31/4188 ,  A61K33/24 ,  A61K51/08 ,  A61K101/00 ,  A61P7/08 ,  A61P35/00 ,  G01N33/574

CPC分类号： A61K38/1709 ,  A61K31/7068 ,  A61K38/42 ,  A61K45/06 ,  A61K47/6445 ,  C07K14/805 ,  A61K2300/00

摘要： The present invention provides a pharmaceutical composition containing recombinant hemoglobin protein or tetramer or dimer or subunit for tissue oxygenation and treating cancer. The recombinant hemoglobin protein or tetramer or dimer or subunit-based therapeutic agent is also effective for treating cancer. The recombinant hemoglobin or tetramer or dimer or its subunit moiety can target cancer cells and the therapeutic moiety (i.e. active agent/therapeutic drug) can kill the cancer cells efficiently. The recombinant hemoglobin or tetramer or dimer or its subunit-based therapeutic agent used in the present invention can be used in the treatment of various cancers such as pancreatic cancer, leukemia, head and neck cancer, colorectal cancer, lung cancer, breast cancer, liver cancer, nasopharyngeal cancer, esophageal cancer, prostate cancer, stomach cancer and brain cancer. The composition can be used alone or in combination with other therapeutic agent(s) such as chemotherapeutic agent, radiotherapeutic agent, anti-cancer protein drug to give a synergistic effect on cancer treatment, inhibiting metastasis and/or reducing recurrence.

摘要翻译： 本发明提供了含有重组蛋白的血红蛋白四聚体或二聚体或亚基或用于组织氧合和治疗癌症的药物组合物。 所述重组蛋白质的血红蛋白四聚体或二聚体或或基于亚基 - 治疗剂是用于治疗癌症非常有效。 重组血红蛋白四聚体或二聚体或或它的亚单位部分可以靶向癌细胞和治疗性部分（即活性剂/治疗药物）能有效地杀死癌细胞。 如胰腺癌，白血病，头颈癌，结肠直肠癌，肺癌，乳腺癌，肝癌：在本发明使用的重组血红蛋白或四聚体或二聚体或它的基于亚基治疗剂可以以各种癌症的治疗中使用 癌，鼻咽癌，食道癌，前列腺癌，胃癌和脑癌。 如化疗剂，放疗剂，抗癌蛋白药物给予癌症治疗，转移抑制和/或减少复发的协同效应：所述组合物可单独使用或与其它治疗剂组合使用。