专利检索 ap:("Chelsea Therapeutics, Inc.") AND inv:"PIMPLASKAR, Harish K." 第 1 页

1.

发明公开
STABLE CRYSTALLINE POLYMORPHS OF THE DIPOTASSIUM SALT OF (S) -2- {4- [2- (2, 4-DIAMIN0-QUINAZ0LIN-6-YL) -ETHYL]-BENZOYLAMINO} -4-METHYLEN -PENTA NEDIOIC ACID 审中-公开
标题翻译：（S）-2- {4- [2-（2-，4- DIAMIN0-CHINAZ0LIN -6-基）乙基] - 苯甲酰氨基} -4-亚甲基戊二酸的稳定的结晶多晶型的二钾盐

公开(公告)号：EP2451788A1

公开(公告)日：2012-05-16

申请号：EP10737145.2

申请日：2010-07-07

申请人： Chelsea Therapeutics, Inc.

发明人： PIMPLASKAR, Harish K. , LEBEDEV, Mikhail , HORVATH, Karol

IPC分类号： C07D239/95 , A61K31/517 , A61P11/06 , A61P19/02 , A61P29/00 , A61P35/00

CPC分类号： C07D239/95

摘要： The present invention provides stable crystalline polymorphic forms of antifolate compounds, particularly (5)-2-{4-[2-(2,4-diamino-quinazolin-6-yl)-ethyl]- benzoylamino}-4-methylene-pentanedioic acid, dipotassium salt, and methods of preparation thereof. The polymorphs may be in the form of hydrates. The invention further provides pharmaceutical compositions comprising the polymorphs and methods of treatment using the polymorphs. The polymorphs are useful in the treatment of multiple conditions, including abnormal cell proliferation, inflammatory diseases, asthma, and arthritis, and the polymorphs may be administered alone in or combination with on or more further active agents.