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    Droxidopa and pharmaceutical composition thereof for the treatment of mood disorders, sleep disorders, or attention deficit disorders
    3.
    发明公开
    Droxidopa and pharmaceutical composition thereof for the treatment of mood disorders, sleep disorders, or attention deficit disorders 审中-公开
    屈昔多巴和药物组合物，情绪障碍，睡眠障碍或注意缺陷障碍的治疗

    公开(公告)号：EP2514417A2

    公开(公告)日：2012-10-24

    申请号：EP12167727.2

    申请日：2008-05-07

    申请人： Chelsea Therapeutics, Inc.

    发明人： Roberts, Michael J. ,  Pedder, Simon

    IPC分类号： A61K31/138 ,  A61K31/195 ,  A61K31/198 ,  A61K31/275 ,  A61K31/345 ,  A61P25/20 ,  A61P25/24 ,  A61P25/28

    CPC分类号： A61K31/198 ,  A61K31/135 ,  A61K31/137 ,  A61K31/138 ,  A61K31/195 ,  A61K31/275 ,  A61K31/277 ,  A61K31/345 ,  A61K31/55 ,  A61K45/06 ,  A61K2300/00

    摘要： The present invention provides pharmaceutical compositions comprising droxidopa alone, or in combination with one or more further active ingredients, for the treatment of conditions, such as mood disorders, sleep disorders, or attention deficit disorders. In certain embodiments, the compositions useful in the methods of the invention comprise droxidopa and a compound selected from the group consisting of DOPA decarboxylase inhibiting compounds, catechol-O-methyltransferase inhibiting compounds, cholinesterase inhibiting compounds, monoamine oxidase inhibiting compounds, norepinephrine reuptake inhibiting compounds, selective serotonin reuptake inhibiting compounds, tricyclic antidepressant compounds, serotonin norepinephrine reuptake inhibiting compounds, norepinephrine dopamine reuptake inhibiting compound, noradrenergic and specific serotonergic antidepressants, and combinations thereof. The inventive compositions are particularly useful in the treatment of depression, narcolepsy, insomnia, and Attention Deficit/Hyperactivity Disorder (AD/HD).

    摘要翻译： 本发明提供药物组合物，包含屈昔多巴单独，或与一种或多种活性成分。此外，为的条件，：如心境障碍，睡眠障碍，或注意力缺陷障碍的治疗。 在某些实施方案中，本发明的方法中有用的组合物包含屈昔多巴和选自DOPA脱羧酶抑制性化合物，儿茶酚-O-甲基转移酶抑制性化合物，胆碱酯酶抑制性化合物，单胺氧化酶抑制性化合物，去甲肾上腺素再摄取抑制的化合物中选择的化合物 ，选择性血清素再摄取抑制的化合物，三环类抗抑郁药的化合物，血清素去甲肾上腺素再摄取抑制的化合物，去甲肾上腺素多巴胺再摄取抑制化合物，去甲肾上腺素和血清素特异性抗抑郁药，以及它们的组合。 本发明组合物是在抑郁症，发作性睡眠，失眠，注意力缺陷/多动症（AD / HD）的治疗中特别有用。

    Droxidopa and pharmaceutical composition thereof for the treatment of fibromyalgia
    4.
    发明公开
    Droxidopa and pharmaceutical composition thereof for the treatment of fibromyalgia 有权
    Pharmazutische Zusammensetzung enthaltend Droxidopa zur Behandlung von Fibromyalgie

    公开(公告)号：EP2468271A1

    公开(公告)日：2012-06-27

    申请号：EP12150107.6

    申请日：2008-03-07

    申请人： Chelsea Therapeutics, Inc.

    发明人： Roberts, Michael J. ,  Pedder, Simon

    IPC分类号： A61K31/195 ,  A61K31/198 ,  A61K31/277 ,  A61K31/435 ,  A61P25/16 ,  A61P25/00

    CPC分类号： A61K31/195 ,  A61K31/198 ,  A61K31/277 ,  A61K31/435 ,  A61K2300/00

    摘要： The present invention provides methods of treating fibromyalgia or other diseases or conditions causing widespread pain and/or fatigue. In particular, the invention provides pharmaceutical compositions comprising droxidopa alone, or in combination with one or more further active agents, that can be used in the inventive methods. The methods of treatment can comprise treating, preventing, reducing, or eliminating a variety of symptoms recognized as indicative of fibromyalgia, such as chronic pain, allodynia, hyperalgesia, fatigue, sleep disturbance, and depression.

    摘要翻译： 本发明提供治疗纤维肌痛或引起广泛的疼痛和/或疲劳的其它疾病或病症的方法。 特别地，本发明提供了药物组合物，其包含单独使用地洛西多或与一种或多种可用于本发明方法的其它活性剂组合。 治疗方法可以包括治疗，预防，减少或消除被认为是指示纤维肌痛的各种症状，例如慢性疼痛，异常性疼痛，痛觉过敏，疲劳，睡眠障碍和抑郁。