公开(公告)号：EP3816161A1

公开(公告)日：2021-05-05

申请号：EP19826745.2

申请日：2019-06-24

申请人： Chia Tai Tianqing Pharmaceutical Group Co., Ltd.

发明人： DONG, Ping ,  HE, Xiongxiong ,  LIU, Lei ,  ZHAO, Rui

IPC分类号： C07D401/12 ,  A61K31/4709 ,  A61P35/00 ,  A61K9/14

摘要： The present application relates to the field of pharmaceutical technology, specifically to the crystal habit and crystalline powder preparation of quinoline derivatives, and more specifically, to the crystal habit and crystalline powder preparation of anlotinib dihydrochloride. The compound of formula II disclosed herein is a crystalline powder with a flaky crystal habit having a specific surface area ≥ 10 m 2 /g and a particle-size distribution of X 50 ≤ 50 µm and/or X 90 ≤ 500 µm, such that a large specific surface area is provided without reducing the particle size of the drug by a physical method under the condition of a broad particle-size distribution, and the drug can rapidly dissolving. In addition to excellent dissolution property, the crystalline powder is also beneficial to industrial manufacturing, featuring simplified process and cost-efficiency.

公开(公告)号：EP3848037A1

公开(公告)日：2021-07-14

申请号：EP19858151.4

申请日：2019-09-03

申请人： Chia Tai Tianqing Pharmaceutical Group Co., Ltd. ,  Lianyungang Runzhong Pharmaceutical Co., Ltd. ,  Centaurus BioPharma Co., Ltd.

发明人： SUN, Yuanyuan ,  ZHOU, Shan ,  LIU, Lei ,  DONG, Ping ,  GAO, Jing ,  LI, Laicun ,  CHEN, Zhilin ,  XU, Yi ,  WANG, Shang

IPC分类号： A61K31/5377 ,  A61P35/00 ,  C07D401/14

摘要： A solid pharmaceutical composition containing a 1,3,5-triazine derivative or a pharmaceutically acceptable salt thereof and a preparation method therefor. In particular, involved are a solid pharmaceutical composition containing 4-( tert- butoxyamino)-6-(6-(trifluoromethyl)pyridin-2-yl)- N -(2-(trifluoromethyl)pyridin-4-yl)-1,3,5-triazine-2-amine or a pharmaceutically acceptable salt thereof and a preparation method therefor. The solid pharmaceutical composition has a good stability, a fast dissolution rate and a high bioavailability, and is suitable for clinical production and use.