公开(公告)号：EP3703058A1

公开(公告)日：2020-09-02

申请号：EP20168461.0

申请日：2006-11-28

申请人： Children's Hospital Medical Center

发明人： GLAUSER, Tracy ,  WENSTRUP, Richard ,  VINKS, Alexander ,  PESTIAN, John

IPC分类号： G16B20/20 ,  C12Q1/68

摘要： A method of selecting a medication for a patient on the basis of an individualized medication report for the patient which comprises a group of possible medications drawn from a set of possible medications that includes at least one medication selected from propranolol, diazepam, alprazolam and risperidone based on the patient's phenotype and scored on the basis of the patient's genotype as determined by a genotyping assay for CYP genes consisting of 1A2, 2B6, 2C9, 2C19, 2D6 and 3A4 using a biological sample obtained from the patient.

公开(公告)号：EP3223182A1

公开(公告)日：2017-09-27

申请号：EP17154177.4

申请日：2006-11-28

申请人： Children's Hospital Medical Center

发明人： GLAUSER, Tracy ,  WENSTRUP, Richard ,  VINKS, Alexander ,  PESTIAN, John

IPC分类号： G06F19/00 ,  C12Q1/68

CPC分类号： G16H50/50 ,  C12Q1/6883 ,  C12Q2600/106 ,  G01N33/94 ,  G06F19/00 ,  G06F19/24 ,  G06F19/326 ,  G06F19/3456 ,  G06Q50/24

摘要： The invention provides population models, methods, and algorithms for targeting a dosing regimen or compound selection to an individual patient. The methods and algorithms of the invention utilize population models that incorporate genotype information for genes encoding drug metabolizing enzymes for one or more compounds of interest. The methods allow integration of genotype information for one or more genes encoding a drug metabolizing enzyme, particularly a cytochrome P450 gene with patient data. The methods allow integration of genotype information and the effect of one or more compounds on one or more drug metabolizing enzymes. The methods allow iterative feedback of drug metabolizing data obtained from a patient into the process of generating a dosage regimen recommendation for a compound of interest for an individual patient.

摘要翻译： 本发明提供了用于将给药方案或化合物选择靶向至个体患者的群体模型，方法和算法。 本发明的方法和算法利用整合编码一种或多种感兴趣化合物的药物代谢酶的基因的基因型信息的群体模型。 该方法允许将编码药物代谢酶，特别是细胞色素P450基因的一种或多种基因的基因型信息与患者数据整合。 该方法允许整合基因型信息和一种或多种化合物对一种或多种药物代谢酶的作用。 该方法允许从患者获得的药物代谢数据的迭代反馈进入为个体患者产生感兴趣化合物的剂量方案推荐的过程。

公开(公告)号：EP2425356B1

公开(公告)日：2019-03-13

申请号：EP10770196.3

申请日：2010-04-27

申请人： Cincinnati Children's Hospital Medical Center

发明人： PESTIAN, John ,  GLAUSER, Tracy, A. ,  ARONOW, Bruce

IPC分类号： G06F17/18 ,  G06F19/00

公开(公告)号：EP2425356A1

公开(公告)日：2012-03-07

申请号：EP10770196.3

申请日：2010-04-27

申请人： Cincinnati Children's Hospital Medical Center

发明人： PESTIAN, John ,  GRUPP-PHELAN, Jackie ,  KOWATCH, Robert ,  GLAUSER, Tracy, A. ,  SMITH, Frank ,  WEIDNER, Norbert

IPC分类号： G06F17/18 ,  G06F19/00

CPC分类号： G16H50/20 ,  G06F19/00 ,  G06N99/005 ,  G16H50/30

摘要： A method for assessing a neuropsychiatric condition (such as, but not limited to, a risk that a subject may attempt to commit suicide or repeat an attempt to commit suicide, a risk that terminally ill patient is not being cared-for or treated according to the patient's true wishes, a risk that a subject may perform or repeat a criminal act and/or a harmful act, a risk of the subject having a psychiatric illness, and/or a risk of a subject feigning a psychiatric illness) may include a plurality of steps. A step may include receiving biomarker data associated from an analysis of the subject's biological sample and a step of receiving thought-marker data obtained pertaining to one or more of the subject's recorded thoughts, spoken words, transcribed speech, and writings. A step may include generating a biomarker score associated with the neuropsychiatric condition from the biomarker data. A step may include generating a thought-marker score associated with the neuropsychiatric condition from the thought-marker data. And a step may involve calculating a neuropsychiatric condition score based, at least in part, upon the biomarker score and the thought-marker score. Such method may be operating from one or more memory devices including computer-readable instructions configured to instruct a computerized system to perform the method, and the method may be operating on a computerized system including one or more computer servers (or other available devices) accessible over a computer network such as the Internet or over some other data network.

公开(公告)号：EP1958111A2

公开(公告)日：2008-08-20

申请号：EP06838538.4

申请日：2006-11-28

申请人： Children's Hospital Medical Center

发明人： GLAUSER, Tracy A. ,  WENSTRUP, Richard J. ,  VINKS, Alexander A. ,  PESTIAN, John

IPC分类号： G06F19/00

CPC分类号： G16H50/50 ,  C12Q1/6883 ,  C12Q2600/106 ,  G01N33/94 ,  G06F19/00 ,  G06F19/24 ,  G06F19/326 ,  G06F19/3456 ,  G06Q50/24

摘要： The invention provides population models, methods, and algorithms for targeting a dosing regimen or compound selection to an individual patient. The methods and algorithms of the invention utilize population models that incorporate genotype information for genes encoding drug metabolizing enzymes for one or more compounds of interest. The methods allow integration of genotype information for one or more genes encoding a drug metabolizing enzyme, particularly a cytochrome P450 gene with patient data. The methods allow integration of genotype information and the effect of one or more compounds on one or more drug metabolizing enzymes. The methods allow iterative feedback of drug metabolizing data obtained from a patient into the process of generating a dosage regimen recommendation for a compound of interest for an individual patient.

摘要翻译： 本发明提供用于将给药方案或化合物选择靶向个体患者的种群模型，方法和算法。 本发明的方法和算法利用对于一种或多种感兴趣的化合物编码药物代谢酶的基因的基因型信息的群体模型。 该方法允许将编码药物代谢酶，特别是细胞色素P450基因的一种或多种基因的基因型信息与患者数据整合。 该方法允许基因型信息的整合以及一种或多种化合物对一种或多种药物代谢酶的影响。 所述方法允许从患者获得的药物代谢数据的迭代反馈到为个体患者感兴趣的化合物产生剂量方案推荐的过程。