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公开(公告)号：EP3177738B1
公开(公告)日：2019-10-09
申请号：EP15828951.2
申请日：2015-08-10
发明人： ROTHENBERG, Marc E. , WEN, Ting , ACEVES, Seema
IPC分类号： C12Q1/6883 , G01N33/68 , A61K31/00 , G16B25/00
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公开(公告)号：EP2723899B1
公开(公告)日：2020-11-18
申请号：EP12802640.8
申请日：2012-06-21
发明人： ROTHENBERG, Marc E. , WEN, Ting
IPC分类号： C12Q1/6883 , G01N33/49 , G01N33/493 , G16B25/00 , G16H50/30 , G01N33/68
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公开(公告)号：EP3177738A1
公开(公告)日：2017-06-14
申请号：EP15828951.2
申请日：2015-08-10
发明人： ROTHENBERG, Marc E. , WEN, Ting , ACEVES, Seema
摘要： The invention provides methods for diagnosing eosinophilic esophagitis in a patient using a biomarker based assay directed to KCNJ2/Kir2.1 and related compositions, kits, and computer program products.
摘要翻译： 本发明提供了使用针对KCNJ2 / Kir2.1及相关组合物，试剂盒和计算机程序产品的基于生物标志物的分析来诊断患者中嗜酸性粒细胞性食管炎的方法。
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公开(公告)号：EP2723899A2
公开(公告)日：2014-04-30
申请号：EP12802640.8
申请日：2012-06-21
发明人： ROTHENBERG, Marc E. , WEN, Ting
CPC分类号： G16H50/30 , C12Q1/6883 , C12Q2600/106 , C12Q2600/158 , G01N33/49 , G01N33/493 , G01N33/6893 , G01N2800/06 , G01N2800/14 , G01N2800/24 , G01N2800/52 , G01N2800/56 , G16B25/00
摘要： Embodiments of the invention are directed to methods of diagnosing eosinophilic esophagitis (EoE), or remission therefrom in a subject, wherein the methods include applying a sample from the subject to a diagnostic panel that contains selected markers for EoE, analyzing to obtain relatedness information relative to an EoE cohort and making a determination as to the EoE status of the subject, wherein an analysis indicating grouping with an EoE cohort or a quantitative score similar to that of an EoE cohort are indicative of EoE in the subject. Embodiments of the invention are also directed to methods of monitoring the pathological development or medical prognosis of EoE in a subject.
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5.发明公开
公开(公告)号：EP2661631A2
公开(公告)日：2013-11-13
申请号：EP12732079.4
申请日：2012-01-06
CPC分类号： C12Q1/6883 , C12Q2600/106 , C12Q2600/112 , C12Q2600/158 , G01N33/6863 , G01N2800/06
摘要： Methods and compositions disclosed herein generally relate to methods of providing or enhancing a diagnosis of eosinophilic esophagitis (EE). In particular, the invention relates to obtaining a sample from a patient having at least one indication of EE, then quantifying from the sample an amount of one or more cytokines associated with EE or an mRNA corresponding to the cytokine or its receptor, wherein an altered level of the cytokine or mRNA correlates with a positive diagnosis of EE. An EE diagnosis can then be provided or enhanced, based upon the quantifying step. The invention further relates to diagnostic kits, tests, and/or arrays that can be used to quantify the one or more cytokines associated with EE or an mRNA corresponding to the cytokine or its receptor.
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