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1.发明公开USE OF FGF- 18 PROTEIN, TARGET PROTEINS AND THEIR RESPECTIVE ENCODING NUCLEOTIDE SEQUENCES TO INDUCE CARTILAGE FORMATION 审中-公开FGF-18蛋白，靶蛋白及其各编码核苷酸序列期感应软骨形成的用途
公开(公告)号：EP1613267A2
公开(公告)日：2006-01-11
申请号：EP04758380.2
申请日：2004-03-26
IPC分类号： A61K6/00
CPC分类号： A61K38/1825 , A01K67/0275 , A01K67/0276 , A01K2217/052 , A01K2217/077 , A01K2217/15 , A01K2217/203 , A01K2227/105 , A01K2267/03 , A61K38/1709 , A61K38/177 , A61K38/18 , A61K38/1841 , A61K38/1875 , A61K48/00 , C07K14/46 , C07K14/50 , Y02A50/411 , A61K2300/00
摘要： The use of fibroblast growth factor (FGF)-18 protein, certain of its downstream target genes and respective expressed proteins, in particular sonic hedgehog (Shh), Shh protein, &bgr;-catenin, &bgr;-catenin protein, and the Wnt family of proteins that stimulate &bgr;-catenin, and the respective nucleotide sequences encoding this protein, particularly for inducing cartilage formation, particularly for the purpose of generating, repairing, reconstructing, or de novo formation of, cartilaginous tissue. Therapies for which FGF-18 and the target proteins are useful include repair and reconstruction of various tissues in conducting airways such as the trachea, bronchi, lung and larynx caused by, for example, tracheal-bronchial abnormalities, tracheal-laryngo or bronchial malaria. Other therapies for which FGF-18 and the target proteins would be useful include other cartilaginous tissues, such as those of joint and skeletal tissue caused by, for example, arthritis and meniscus abnormalities in joints.
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2.发明公开CFTR MODIFIER GENES AND EXPRESSED POLYPEPTIDES USEFUL IN TREATING CYSTIC FIBROSIS AND METHODS AND PRODUCTS FOR DETECTING AND/OR IDENTIFYING SAME 审中-公开CFTR修饰基因以及参与囊性纤维化合适的，程序及其产品，以证明和/或标识的处理表达多肽
公开(公告)号：EP1513870A2
公开(公告)日：2005-03-16
申请号：EP03734252.4
申请日：2003-05-30
IPC分类号： C07K14/00
CPC分类号： C07K14/4712
摘要： The discovery that CFTR modifier genes, in particular the Kir4.2 gene, the expressed polypeptide(s), as well as genetic and polypeptide regulators thereof, can be used to treat cystic fibrosis (CF), or at least the conditions that cause CF. Methods and products for detecting and/or identifying CFTR modifier genes, their respective expressed polypeptides, the genetic regulators of such CFTR modifier genes, and the regulators of their respective expressed polypeptides are disclosed. Also disclosed are compositions and methods using these CFTR modifier genes, their respective expressed polypeptides, genetic regulators of these CFTR modifier genes, and/or CFTR modifier polypeptide regulators for the purpose of treating CF, or at least the conditions that cause CF, are disclosed.
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