公开(公告)号：EP3512879A1

公开(公告)日：2019-07-24

申请号：EP17851188.7

申请日：2017-09-15

申请人： Chugai Seiyaku Kabushiki Kaisha ,  Agency for Science, Technology and Research

发明人： SAMPEI, Zenjiro ,  KOO, Xing'er Christine ,  FINK, Katja ,  ZUEST, Roland

IPC分类号： C07K16/10 ,  A61K39/42 ,  A61P31/12

公开(公告)号：EP3765494A1

公开(公告)日：2021-01-20

申请号：EP19767801.4

申请日：2019-03-15

申请人： CHUGAI SEIYAKU KABUSHIKI KAISHA ,  Agency for Science, Technology and Research

发明人： FINK, Katja ,  WANG, Cheng-I ,  NG, Lisa Fong Poh ,  RENIA, Laurent ,  SAMPEI, Zenjiro ,  KOO, Xing'er Christine

IPC分类号： C07K16/10 ,  A61K39/42 ,  A61P31/12

公开(公告)号：EP3740577A1

公开(公告)日：2020-11-25

申请号：EP19741912.0

申请日：2019-01-17

申请人： Nanyang Technological University ,  Agency for Science, Technology and Research

发明人： LUO, Dahai ,  FINK, Katja ,  YONG, Hui Yee ,  HO, Chin Yong Victor

IPC分类号： C12N15/113 ,  A61K31/7105 ,  A61P31/00 ,  A61P35/00 ,  A61P37/00

公开(公告)号：EP2897628A1

公开(公告)日：2015-07-29

申请号：EP13839125.5

申请日：2013-09-23

申请人： Agency for Science, Technology and Research ,  Novartis AG ,  Beijing Institute of Microbiology and Epidemiology

发明人： FINK, Katja ,  SHI, Pei-Yong ,  QIN, Cheng Feng

IPC分类号： A61K35/76 ,  A61P31/12 ,  C12N15/40

CPC分类号： A61K39/12 ,  A61K2039/5254 ,  C07K14/005 ,  C12N2770/24122 ,  C12N2770/24134 ,  C12N2770/24162 ,  Y02A50/386

摘要： The present invention discloses a method of eliciting an immune response and a method of vaccination comprising administration of a mutated flavivirus. The mutated flavivirus comprises at least one mutation in a nucleic acid sequence encoding for the non-structural protein 5 of the flavivirus sequence resulting in inactivation of the 2′O-methyltransferase.

公开(公告)号：EP3271390A1

公开(公告)日：2018-01-24

申请号：EP16765356.7

申请日：2016-03-17

申请人： Agency for Science, Technology and Research ,  National University of Singapore

发明人： WANG, Cheng-I ,  FINK, Katja ,  MACARY, Paul ,  ZUEST, Roland ,  XU, Meihui

IPC分类号： C07K16/10 ,  A61K39/42 ,  A61P31/12 ,  G01N33/569

CPC分类号： C07K16/1081 ,  A61K2039/505 ,  A61P31/12 ,  C07K2317/34 ,  C07K2317/76 ,  G01N33/56983 ,  G01N2333/185 ,  Y02A50/386 ,  Y02A50/53

摘要： Disclosed are isolated antibodies, or antigen binding fragments thereof, that bind to dengue virus epitopes, as well as kits containing them, compositions containing them, and passive vaccines comprising them, in one embodiment, the antibody or antigen binding fragment thereof is capable of binding to a whole dengue virus particle better than binding to a dengue virus surface glycoprotein. Also disclosed are methods of using the antibodies or antigen binding fragments thereof, nucleic acids encoding them, vectors expressing the nucleic acids, host producing them, and methods of manufacturing them.