公开(公告)号：EP2995300B1

公开(公告)日：2020-04-22

申请号：EP13875242.3

申请日：2013-12-19

申请人： Chung-Ang University Industry-Academic Cooperation Foundation

发明人： LEE, Kangseok ,  BAE, Jeehyeon ,  SEONG, Maeng Je ,  HAN, Min Su ,  YEOM, Ji Hyun ,  RYOU, Sang Mi ,  HA, Nam Chul

IPC分类号： A61K47/54 ,  A61K47/69 ,  A61P35/00 ,  A61K38/00 ,  C12N15/115

公开(公告)号：EP2995300A1

公开(公告)日：2016-03-16

申请号：EP13875242.3

申请日：2013-12-19

申请人： Chung-Ang University Industry-Academic Cooperation Foundation

发明人： LEE, Kangseok ,  BAE, Jeehyeon ,  SEONG, Maeng Je ,  HAN, Min Su ,  YEOM, Ji Hyun ,  RYOU, Sang Mi ,  HA, Nam Chul

IPC分类号： A61K9/16 ,  A61K9/14 ,  A61K47/48 ,  C12N15/115

摘要： The present invention relates to a protein transduction domain comprising gold nanoparticles and aptamers binding to the surfaces of the gold nanoparticles. The protein transduction domain according to the present invention is expected to be useful for diagnosing or treating diseases since the protein transduction domain specifically binds to proteins, which are to be delivered by various tagged aptamers or protein-specific aptamers binding to gold nanoparticles, thereby effectively delivering the proteins into cells, can be harmless to humans by using gold nanoparticles having very little cytotoxicity, and allows easy confirmation of the intercellular position thereof by reflecting lights of various wavelengths.

摘要翻译： 本发明涉及一种蛋白质转导结构域包含金纳米颗粒和适体结合的金纳米颗粒的表面上。 蛋白转导域雅丁到，本发明预期可用于诊断或治疗疾病，因为所述蛋白转导结构域特异性结合蛋白，其是通过各种标记的适体或蛋白质特异性的适体结合的金纳米颗粒被输送，从而有效地有用 递送蛋白到细胞中，可以通过使用具有非常小的细胞毒性的金纳米颗粒对人体无害，并且其通过反映各种波长的光允许细胞间位置的容易确认。