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1.发明公开Method for preparing recombinant antigen complex using rotavirus nanoparticle 有权一种用于使用轮状病毒纳米颗粒制备重组抗原复杂的过程
公开(公告)号：EP2382989A1
公开(公告)日：2011-11-02
申请号：EP11163914.2
申请日：2011-04-27
发明人： Kim, Won Yong , Chung, In Sik , Kim, Jong-Bum , Shon, Dong-Hwa , Than, Van Thai , Yoon, Jang Won , Park, Joo Hyoung , Baek, In-Hyuk
CPC分类号： A61K39/29 , A61K39/12 , A61K39/15 , A61K2039/5256 , A61K2039/5258 , A61K2039/55566 , A61K2039/627 , A61K2039/64 , C07K14/005 , C07K2319/00 , C12N2710/14143 , C12N2720/12322 , C12N2720/12334 , C12N2770/32234 , C12N2770/32422 , C12N2770/32434 , G01N33/56983 , G01N2333/14 , Y02A50/464
摘要： Disclosed are a construct for expressing a rotavirus antigen complex loaded with a heterologous virus epitope, a vaccine composition containing the rotavirus antigen complex, a virus-like particle of rotavirus containing the rotavirus antigen complex, and a vaccine composition containing the virus-like particle of rotavirus. According to the present disclosure, an antigen complex containing a rotavirus antigen as well as a heterologous virus epitope and a virus-like particle of rotavirus containing the antigen complex can be produced in large scale at low cost. Thus, the present disclosure may be applied for research and development of novel complex vaccines for rotavirus and heterologous virus.
摘要翻译： 本发明公开了用于表达载有异源病毒表位，疫苗组合物包含的轮状病毒抗原复合物，含有该轮状病毒抗原复合轮状病毒的病毒样颗粒，以及含有的病毒样颗粒的疫苗组合物中的轮状病毒抗原复合物的构建体 轮状病毒。 。根据本公开，对抗原复合物含一个轮状病毒抗原以及异源病毒的表位和包含抗原复合轮状病毒的病毒样颗粒可以在大规模低成本地制造。 因此，本发明可以应用于研究和轮状病毒复杂和异源病毒的新型疫苗的发展。
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2.发明授权Method for preparing recombinant antigen complex using rotavirus nanoparticle 有权一种用于使用轮状病毒纳米颗粒制备重组抗原复杂的过程
公开(公告)号：EP2382989B1
公开(公告)日：2016-06-29
申请号：EP11163914.2
申请日：2011-04-27
发明人： Kim, Won Yong , Chung, In Sik , Kim, Jong-Bum , Shon, Dong-Hwa , Than, Van Thai , Yoon, Jang Won , Park, Joo Hyoung , Baek, In-Hyuk
CPC分类号： A61K39/29 , A61K39/12 , A61K39/15 , A61K2039/5256 , A61K2039/5258 , A61K2039/55566 , A61K2039/627 , A61K2039/64 , C07K14/005 , C07K2319/00 , C12N2710/14143 , C12N2720/12322 , C12N2720/12334 , C12N2770/32234 , C12N2770/32422 , C12N2770/32434 , G01N33/56983 , G01N2333/14 , Y02A50/464
摘要： Disclosed are a construct for expressing a rotavirus antigen complex loaded with a heterologous virus epitope, a vaccine composition containing the rotavirus antigen complex, a virus-like particle of rotavirus containing the rotavirus antigen complex, and a vaccine composition containing the virus-like particle of rotavirus. According to the present disclosure, an antigen complex containing a rotavirus antigen as well as a heterologous virus epitope and a virus-like particle of rotavirus containing the antigen complex can be produced in large scale at low cost. Thus, the present disclosure may be applied for research and development of novel complex vaccines for rotavirus and heterologous virus.
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