公开(公告)号：EP4155312A1

公开(公告)日：2023-03-29

申请号：EP21809650.1

申请日：2021-05-18

申请人： Cisen Pharmaceutical Co., Ltd.

发明人： CHEN, Shuhui ,  FENG, Jiajie ,  WEI, Wei ,  LI, Peng ,  HE, Haiying ,  LIU, Jinxin ,  LI, Jian

IPC分类号： C07D498/14 ,  C07D471/14

摘要： Disclosed are a kind of fused ring derivatives, and specifically disclosed are compounds as shown in formula (I) and pharmaceutically acceptable salts thereof.

公开(公告)号：EP2786998B1

公开(公告)日：2018-07-25

申请号：EP12853993.9

申请日：2012-10-23

申请人： Shanghai Institute of Materia Medica, Chinese Academy of Sciences ,  Cisen Pharmaceutical Co., Ltd.

发明人： LIU, Hong ,  LI, Jia ,  LI, Jian ,  LI, Jingya ,  WANG, Jiang ,  SU, Mingbo ,  LIAN, Jie ,  JIANG, Hualiang ,  CHEN, Kaixian

IPC分类号： C07D495/04 ,  A61K31/519 ,  A61K31/55 ,  A61P3/10

CPC分类号： C07D495/04

摘要： Disclosed are new thienyl [3, 2-d] pyrimidin-4-one compounds shown as the general formula (I), preparation method, pharmaceutical compositions and pharmacological use thereof. The compounds are strong DPPIV (dipeptide peptidase IV) inhibitors and can treat type II diabetes through well inhibiting DPPIV indirectly increasing the content of GLP-1 in vivo and inducing a series of physiological actions in vivo. Therefore, the compounds could be developed as new promising drugs for treating diabetes.

公开(公告)号：EP4046999A1

公开(公告)日：2022-08-24

申请号：EP20877068.5

申请日：2020-10-16

申请人： Cisen Pharmaceutical Co., Ltd.

发明人： ZHOU, Ming ,  XU, Zhaobing ,  LI, Gang ,  HU, Lihong ,  DING, Charles Z. ,  JIANG, Wen ,  HU, Guoping ,  LI, Jian ,  CHEN, Shuhui

IPC分类号： C07D471/04 ,  A61K31/519 ,  A61P35/00

摘要： Disclosed is an aminopyrimidine compound as a CDK2/4/6 inhibitor, and specifically disclosed are the compound represented by formula (I) and a pharmaceutically acceptable salt thereof, and an application of the compound represented by formula (I) and the pharmaceutically acceptable salt thereof in the preparation of a medicament for treating solid tumor.