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1.发明公开
公开(公告)号：EP3482773A1
公开(公告)日：2019-05-15
申请号：EP18189020.3
申请日：2011-10-10
申请人： City of Hope
发明人： WILLIAMS, John C. , DONALDSON, Joshua Michael , HORNE, David, A. , MA, Yuelong , ZER, Cindy , BZYMEK, Krzysztof , AVERY, Kendra Nicole
摘要： An antibody framework binding interface for the cyclic meditopes C-QFDLSTRRLK-C (cQFD; SEQ ID NO:1) and C-QYNLSSRALK-C (cQYN; SEQ ID NO:2) and methods for their use are provided herein. In one embodiment, a binding interface is formed by a framework region, and not a complementarity determining region (CDR), of an antibody or functional fragment thereof. In another embodiment, a therapeutic human or humanized antibody has one or more human framework residues replaced with one or more corresponding murine residues such that a meditope having the sequence cQFD or cQYN stably binds the one or more human framework residues.
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公开(公告)号：EP2624868B1
公开(公告)日：2018-09-26
申请号：EP11831753.6
申请日：2011-10-10
申请人： City of Hope
发明人： WILLIAMS, John C. , DONALDSON, Joshua Michael , HORNE, David, A. , MA, Yuelong , ZER, Cindy , BZYMEK, Krzysztof , AVERY, Kendra Nicole
IPC分类号： A61K39/395 , A61K39/00 , A61K39/38 , C07K16/00 , C07K7/64 , C07K16/44 , C07K1/22 , A61K47/62
CPC分类号： C07K16/2863 , A61K47/66 , A61K47/6851 , A61K47/6897 , B82Y5/00 , C07K7/64 , C07K16/32 , C07K16/44 , C07K2317/34 , C07K2317/55 , C07K2317/567 , C07K2317/622 , C07K2317/73 , C07K2317/92 , C07K2319/30
摘要： Meditope variants and methods for their use are provided herein. A meditope variant as described herein comprises a peptide having a sequence CQFDLSTRRLKC (SEQ ID NO:1) or CQYNLSSRALKC (SEQ ID NO:2) that has one or more modifications at of least one amino acid residue of the sequence. Multivalent meditope variant tethering entities are also provided. Such entities may include two or more meditopes coupled via a long linker, multivalent scaffold, biotin-streptavidin, or IgG Fc domain. Further, methods of treating, imaging or diagnosing a disease or condition are provided. Such methods may include administering a therapeutically effective amount of a pharmaceutical composition to a subject, the pharmaceutical compound comprising an antibody-meditope complex; a multivalent tethering agent in combination with a monoclonal antibody or functional fragment thereof; or a combination thereof.
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公开(公告)号：EP2766382A1
公开(公告)日：2014-08-20
申请号：EP12839868.2
申请日：2012-04-10
申请人： City of Hope
发明人： WILLIAMS, John C. , HORNE, David A. , MA, Yuelong , CHANG, Heng Wei , DONALDSON, Joshua Michael , ZER, Cindy , BZYMEK, Krzysztof , AVERY, Kendra Nicole , XIE, Jun
摘要： Antibodies and meditopes that bind to the antibodies are provided, as well as complexes, compositions and combinations containing the meditopes and antibodies, and methods of producing, using, testing, and screening the same, including therapeutic and diagnostic methods and uses.
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公开(公告)号：EP3741773A1
公开(公告)日：2020-11-25
申请号：EP20164995.1
申请日：2012-04-10
申请人： City of Hope
发明人： WILLIAMS, John C. , HORNE, David A. , MA, Yuelong , CHANG, Heng Wei , DONALDSON, Joshua Michael , ZER, Cindy , BZYMEK, Krzysztof , AVERY, Kendra Nicole , XIE, Jun
摘要： Antibodies and meditopes that bind to the antibodies are provided, as well as complexes, compositions and combinations containing the meditopes and antibodies, and methods of producing, using, testing, and screening the same, including therapeutic and diagnostic methods and uses.
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公开(公告)号：EP2766382B1
公开(公告)日：2020-05-06
申请号：EP12839868.2
申请日：2012-04-10
申请人： City of Hope
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