公开(公告)号：EP3386549A1

公开(公告)日：2018-10-17

申请号：EP16874014.0

申请日：2016-12-09

申请人： City of Hope

发明人： HERRMANN, Andreas ,  YU, Hua ,  LAHTZ, Christoph

IPC分类号： A61K47/50 ,  C09B23/00

CPC分类号： C09B23/0066 ,  A61K47/545 ,  C09B23/06 ,  C09B23/083

摘要： Described herein are compositions relating to cell-penetrating conjugates of formula (I) or (IV). The compositions are capable of penetrating cells and recognizing intracellular targets (e.g., STAT3) and are, inter alia, useful for diagnostic and therapeutic purposes.

公开(公告)号：EP3795168A1

公开(公告)日：2021-03-24

申请号：EP20190286.3

申请日：2016-01-15

申请人： City of Hope

发明人： HERRMANN, Andreas ,  YU, Hua

IPC分类号： A61K38/14 ,  A61K47/54 ,  A61K39/08 ,  C07K16/18 ,  C07K16/00 ,  A61P35/00 ,  C12N15/11 ,  A61K38/00

摘要： Provided herein are cell penetrating conjugates. The conjugates include a non- cell penetrating protein attached to a phosphorothioate nucleic acid or phosphorothioate polymer backbone through a non-covalent linker including abiotin-binding domain and a biotin domain, wherein the phosphorothioate nucleic acid or phosphorothioate polymer backbone enhances intracellular delivery of the non-cell penetrating protein. Also provided are compositions and kits comprising the conjugates.

公开(公告)号：EP3244910B1

公开(公告)日：2020-09-16

申请号：EP16737990.8

申请日：2016-01-15

申请人： City of Hope

发明人： HERRMANN, Andreas ,  YU, Hua

IPC分类号： A61K38/14 ,  A61P35/00 ,  C07K16/18 ,  A61K39/08 ,  A61K47/50 ,  A61K47/54

公开(公告)号：EP2125855A2

公开(公告)日：2009-12-02

申请号：EP07868108.7

申请日：2007-12-28

申请人： City of Hope

发明人： YU, Hua ,  KORTYLEWSKI, Marcin ,  JOVE, Richard ,  ROSSI, John, J. ,  SWIDERSKI, Piotr

IPC分类号： C07H21/02 ,  C07H21/04 ,  A01N43/04 ,  A61K31/70

CPC分类号： C07H21/02 ,  A61K31/7105 ,  A61K31/713 ,  A61K47/549

摘要： The present invention relates to methods and compositions for the treatment of diseases, including cancer, infectious diseases and autoimmune diseases. The present invention also relates to methods and compositions for improving immune function. More particularly, the present invention relates to multifunctional molecules that are capable of being delivered to cells of interest for the treatment of diseases and for the improvement in immune function.

公开(公告)号：EP4200335A1

公开(公告)日：2023-06-28

申请号：EP21859254.1

申请日：2021-08-20

申请人： City of Hope

发明人： YU, Hua ,  ZHANG, Chunyan

IPC分类号： C07K16/28 ,  A61K39/395 ,  A61P35/00 ,  C07K16/46

公开(公告)号：EP4153762A2

公开(公告)日：2023-03-29

申请号：EP21807816.0

申请日：2021-05-21

申请人： City of Hope

发明人： YU, Hua ,  LI, Yi-Jia ,  HERRMANN, Andreas

IPC分类号： C12N15/90 ,  C12N9/22 ,  C12P19/34

公开(公告)号：EP3331573A1

公开(公告)日：2018-06-13

申请号：EP16833942.2

申请日：2016-08-05

申请人： City of Hope

发明人： YU, Hua ,  HERRMANN, Andreas

IPC分类号： A61K49/00 ,  A61P35/00 ,  C12Q1/68

CPC分类号： A61K47/6851 ,  A61K47/6809 ,  A61K47/6869 ,  C07K16/3069 ,  C07K16/32 ,  C07K2317/24 ,  C07K2317/622 ,  C12N15/113 ,  C12N2310/14 ,  C12Q1/68 ,  C12Q1/6804 ,  C12Q2525/113 ,  C12Q2525/207 ,  C12Q2563/131

摘要： Provided herein are cell penetrating conjugates. The conjugates include a non-cell penetrating protein, a phosphorothioate nucleic acid, a first linker attaching the phosphorothioate nucleic acid to the non-cell penetrating protein and a second linker attaching the phosphorothioate nucleic acid to a therapeutic moiety (e.g., siRNA or small molecule), wherein the phosphorothioate nucleic acid enhances the intracellular delivery of the non-cell penetrating protein. The conjugates provided herein are, inter alia, useful for the treatment of cancer.

公开(公告)号：EP3331543A1

公开(公告)日：2018-06-13

申请号：EP16833941.4

申请日：2016-08-05

申请人： City of Hope

发明人： HERRMANN, Andreas ,  YU, Hua

IPC分类号： A61K38/00 ,  A61K38/14 ,  A61K39/00 ,  A61K47/00

CPC分类号： C07K16/468 ,  A61K38/00 ,  A61K38/14 ,  A61K47/549 ,  A61K47/6843 ,  A61K47/6851 ,  A61K47/6871 ,  A61K47/6879 ,  A61K47/6889 ,  A61K2039/505 ,  A61P35/00 ,  C07K16/00 ,  C07K16/18 ,  C07K16/30 ,  C07K16/40 ,  C07K2317/24 ,  C07K2317/31 ,  C07K2317/40 ,  C07K2317/622 ,  C07K2317/77

摘要： Provided herein are cell penetrating conjugates. The conjugates include non-cell penetrating proteins connected through a phosphorothioate nucleic acid, wherein the phosphorothioate nucleic acid enhances intracellular delivery of the non-cell penetrating proteins. Also provided are methods and kits including the conjugates provided herein.

公开(公告)号：EP3244910A1

公开(公告)日：2017-11-22

申请号：EP16737990.8

申请日：2016-01-15

申请人： City of Hope

发明人： HERRMANN, Andreas ,  YU, Hua

IPC分类号： A61K38/14 ,  A61K47/50 ,  A61K39/08

摘要： Provided herein are cell penetrating conjugates. The conjugates include a non-cell penetrating protein attached to a phosphorothioate nucleic acid or phosphorothioate polymer backbone through a non-covalent linker including abiotin-binding domain and a biotin domain, wherein the phosphorothioate nucleic acid or phosphorothioate polymer backbone enhances intracellular delivery of the non-cell penetrating protein. Also provided are compositions and kits comprising the conjugates.

公开(公告)号：EP3038639A1

公开(公告)日：2016-07-06

申请号：EP14839093.3

申请日：2014-08-29

申请人： City of Hope

发明人： LI, Lin ,  SHIVELY, John Ernest ,  SWIDERSKI, Piotr Marek ,  HERRMANN, Andreas ,  YU, Hua

IPC分类号： A61K38/14

CPC分类号： A61K47/48092 ,  A61K38/00 ,  A61K39/44 ,  A61K47/549 ,  A61K47/6807 ,  A61K47/6843 ,  A61K2039/505 ,  A61K2039/507 ,  C07K16/084 ,  C07K16/18 ,  C07K16/40 ,  C07K2317/73 ,  C07K2317/76 ,  C07K2319/10

摘要： Provided herein are cell penetrating conjugates. The conjugates include a non-cell penetrating protein attached to a phosphorothioate nucleic acid or phosphorothioate polymer backbone, wherein the phosphorothioate nucleic acid or phosphorothioate polymer backbone enhances intracellular delivery of the non-cell penetrating protein. Also provided are compositions and kits comprising the cojugates.