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1.
公开(公告)号:EP3707246A1
公开(公告)日:2020-09-16
申请号:EP18819234.8
申请日:2018-11-07
申请人: City of Hope , Wang, Xiuli , Forman, Stephen J.
发明人: WANG, Xiuli , FORMAN, Stephen J.
IPC分类号: C12N5/0783 , A61K35/17 , A61K39/00 , A61P35/02
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公开(公告)号:EP4219530A1
公开(公告)日:2023-08-02
申请号:EP22208847.8
申请日:2015-12-07
申请人: City of Hope
发明人: FORMAN, Stephen J. , WANG, Xiuli
摘要: Chimeric antigen receptors for use in treating malignant melanoma and other cancers expressing CS1 are described.
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3.
公开(公告)号:EP3600352A1
公开(公告)日:2020-02-05
申请号:EP18718975.8
申请日:2018-03-20
申请人: City of Hope
发明人: WANG, Xiuli , FORMAN, Stephen J.
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公开(公告)号:EP3370743A1
公开(公告)日:2018-09-12
申请号:EP16863030.9
申请日:2016-11-04
申请人: City of Hope
发明人: FORMAN, Stephen J. , WANG, Xiuli
IPC分类号: A61K35/17 , A61K39/395 , C07K14/705 , C07K14/725 , C07K16/28 , C07K16/30
CPC分类号: C12N5/0636 , A61K35/17 , C07K14/7051 , C07K14/70514 , C07K14/70517 , C07K14/70521 , C07K14/70578 , C07K16/2803 , C07K16/30 , C07K2317/622 , C07K2319/00 , C07K2319/02 , C07K2319/03 , C12N5/00 , C12N2501/2302 , C12N2501/2315 , C12N2501/999
摘要: An improved method for preparing T cell populations expressing a chimeric antigen receptor is described.
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公开(公告)号:EP3324984A1
公开(公告)日:2018-05-30
申请号:EP16828557.5
申请日:2016-07-21
申请人: City of Hope
IPC分类号: A61K35/17
CPC分类号: A61K35/17 , C12N5/0636 , C12N2510/00
摘要: Methods for preparing T cell populations useful for a variety of purposes requiring a highly active, long-lived T cell population. The T cell populations are enriched for: nave T cells (TN), memory stem cells (TSCM) and central memory T cells (TCM). These cell populations can be derived from peripheral blood mononuclear cells (PBMC) by both: 1) depleting unwanted cell populations such as CD14 expressing myeloid cells and CD25 expressing cells; and 2) enriching for CD62L expressing memory and nave T cells.
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6.
公开(公告)号:EP4210831A2
公开(公告)日:2023-07-19
申请号:EP21791096.7
申请日:2021-09-09
申请人: Mustang Bio, Inc. , City of Hope
IPC分类号: A61P35/00 , A61K38/17 , A61K35/17 , A61K35/763 , A61K39/00 , C07K14/725
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7.
公开(公告)号:EP4118106A1
公开(公告)日:2023-01-18
申请号:EP21717627.0
申请日:2021-03-12
申请人: City of Hope
IPC分类号: C07K14/705 , C07K14/715 , C07K14/725 , C07K14/54 , A61K39/00 , A61P35/00 , C12N5/078
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公开(公告)号:EP4074731A1
公开(公告)日:2022-10-19
申请号:EP22157943.6
申请日:2016-11-04
申请人: City of Hope
IPC分类号: C07K16/28 , C07K16/30 , C07K14/705 , C12N5/10 , C12N15/79 , C07K14/725 , A61K39/00 , A61P35/00 , A61K35/17 , C07K14/71 , C07K16/32 , C12N5/0783 , C12N15/86
摘要: Chimeric transmembrane immunoreceptors (CAR) which include an extracellular domain targeted to HER2, a transmembrane region, a costimulatory domain and an intracellular signaling domain are described.
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公开(公告)号:EP3359574A1
公开(公告)日:2018-08-15
申请号:EP16787625.9
申请日:2016-10-06
申请人: City of Hope
摘要: Chimeric transmembrane immunoreceptors (CAR) targeted to PSCA are described.
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10.
公开(公告)号:EP4054598A1
公开(公告)日:2022-09-14
申请号:EP20816769.2
申请日:2020-11-05
申请人: City of Hope
IPC分类号: A61K35/17 , C07K14/705 , C12N5/0783 , C12N5/074
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