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    ORAL BIOFILM MODELS AND USES THEREOF
    5.
    发明公开
    ORAL BIOFILM MODELS AND USES THEREOF 审中-公开
    口腔生物膜模型及其用途

    公开(公告)号：EP3194561A1

    公开(公告)日：2017-07-26

    申请号：EP14796930.7

    申请日：2014-10-06

    申请人： Colgate-Palmolive Company

    发明人： RINAUDI MARRON, Luciana ,  SULLIVAN, Richard ,  SURIANO, David ,  REGE, Aarti ,  SANTARPIA III, Ralph Peter

    IPC分类号： C12M1/12 ,  C12Q1/18

    CPC分类号： C12Q1/18 ,  C12N1/20 ,  G01N1/2806

    摘要： The present disclosure provides an oral biofilm model including a substrate including a first surface, a second surface, and a plurality of specimens fixedly attached to the first surface, wherein an oral biofilm is capable of forming on the specimen. The surface roughness of at least one of the specimens of the plurality is less than or greater than a surface roughness of at least a second specimen of the plurality. The oral biofilm model also includes a body having sides and a bottom defining a vessel. The body is adapted to receive the substrate and the plurality of specimens and is further adapted to receive a fluid. Methods of forming oral biofilms and methods for identifying an agent for reducing or inhibiting biofilm formation are also provided.

    摘要翻译： 本公开提供了一种口腔生物膜模型，其包括基底，所述基底包括第一表面，第二表面和固定地附着于所述第一表面的多个样本，其中能够在所述样本上形成口腔生物膜。 所述多个样本中的至少一个样本的表面粗糙度小于或大于所述多个样本中的至少第二样本的表面粗糙度。 口腔生物膜模型还包括具有限定血管的侧面和底部的主体。 主体适于接收基底和多个样本并且还适于接收流体。 还提供了形成口腔生物膜的方法和用于鉴定用于减少或抑制生物膜形成的试剂的方法。