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1.发明公开PROCÉDÉ ET DISPOSITIF POUR DÉTECTER EN TEMPS RÉEL UN COMPOSÉ SÉCRÉTÉ ET LA CIBLE SÉCRÉTRICE AINSI QUE LEURS UTILISATIONS 审中-公开用于实时检测分泌化合物和筛选靶的方法和装置及其用途
公开(公告)号：EP3265809A1
公开(公告)日：2018-01-10
申请号：EP16709316.0
申请日：2016-03-04
申请人： Commissariat à l'Énergie Atomique et aux Énergies Alternatives , Centre National de la Recherche Scientifique
发明人： ROUPIOZ, Yoann , LEROY, Loïc , MARCHE, Patrice , DELLEA, Olivier , CUBIZOLLES, Myriam , HERRIER, Cyril , LIVACHE, Thierry
IPC分类号： G01N33/50 , G01N33/543 , G01N33/53
CPC分类号： G01N33/5005 , G01N33/5038 , G01N33/5302 , G01N33/54373 , G01N33/6863
摘要： The present invention relates to a method for measuring in real time the secretion of a compound C
o by a target C
i , said method comprising: culturing, in a liquid medium, in a culture chamber, a plurality of targets including at least one target C
i , said culture chamber comprising: (i) at least one 1st surface on which said target C
i is present, the presence of said target C
i generating a 1st signal; and (ii) at least one 2
nd surface that is different from said 1st surface and not coplanar with said 1st surface, which surface is functionalised by at least one ligand specifically binding to said compound C
o secreted by said target C
i , the specific bond between said ligand and said compound C
o generating a 2nd signal that is distinct from said 1st signal; and detecting in real time said 2nd signal and optionally said 1st signal. The present invention also relates to devices possibly implemented in such a method.-
公开(公告)号：EP3265809B1
公开(公告)日：2019-05-29
申请号：EP16709316.0
申请日：2016-03-04
申请人： Commissariat à l'Énergie Atomique et aux Énergies Alternatives , Centre National de la Recherche Scientifique
发明人： ROUPIOZ, Yoann , LEROY, Loïc , MARCHE, Patrice , DELLEA, Olivier , CUBIZOLLES, Myriam , HERRIER, Cyril , LIVACHE, Thierry
IPC分类号： G01N33/50 , G01N33/543 , G01N33/53
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公开(公告)号：EP4136430A1
公开(公告)日：2023-02-22
申请号：EP21732487.0
申请日：2021-05-26
申请人： Commissariat à l'Energie Atomique et aux Energies Alternatives , UNIVERSITÉ GRENOBLE ALPES , CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE
IPC分类号： G01N21/552 , G01N27/414 , G01N33/543 , G01N33/94 , G01N33/569 , C12Q1/10
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