公开(公告)号：EP3394613B1

公开(公告)日：2019-10-09

申请号：EP16826332.5

申请日：2016-12-22

申请人： Commissariat à l'énergie atomique et aux énergies alternatives ,  Orano Cycle

发明人： GRIFFITHS, Nina ,  VAN DER MEEREN, Anne

IPC分类号： G01N33/487

公开(公告)号：EP3394613A1

公开(公告)日：2018-10-31

申请号：EP16826332.5

申请日：2016-12-22

申请人： Commissariat à l'Energie Atomique et aux Energies Alternatives ,  Orano Cycle

发明人： GRIFFITHS, Nina ,  VAN DER MEEREN, Anne

IPC分类号： G01N33/487

CPC分类号： G01N33/48714 ,  A61K31/721 ,  A61K31/722 ,  A61K31/723 ,  G01N33/5008 ,  G01N33/84 ,  G01N33/94 ,  G01T1/161 ,  G01T1/167

摘要： The invention relates to a method for predicting the bioavailability of a radioelement in an animal living organism following the contamination of said organism by said radioelement, said method comprising the steps of: (a) producing a gel imitating the area of contamination in said animal living organism and in which said radioelment is uniformly distributed; (b) bringing the gel produced in said step (a) into contact with a solution imitating a biological fluid associated with the area of contamination in said animal living organism, then stirring the mixture; and (c) measuring the quantity of said radioelement in said solution at a given moment t, said measurement allowing the prediction of the bioavailability of said radioelement in said animal living organism. The invention also relates to the use of such a method for identifying a molecule exhibiting chelating properties in relation to a given radioelement and/or for characterising the chelating properties of a molecule.