公开(公告)号：EP2492719B1

公开(公告)日：2014-12-03

申请号：EP12156772.1

申请日：2012-02-23

申请人： CooperVision International Holding Company, LP

发明人： Francis A Charles ,  Zheng, Ying ,  Xu, Yuan ,  Yao, Li ,  Back, Arthur ,  Hong, Ye ,  Chen, Charlie

IPC分类号： C08L83/04 ,  G02B1/04

CPC分类号： G02B1/043 ,  C08G77/20 ,  C08G77/46 ,  C08L83/04 ,  C08L101/14 ,  C08L51/085 ,  C08L101/04 ,  C08L83/00 ,  C08L83/12

公开(公告)号：EP2492720B1

公开(公告)日：2013-11-20

申请号：EP12156774.7

申请日：2012-02-23

申请人： CooperVision International Holding Company, LP

发明人： Liu, Yuwen ,  Chen, Charlie ,  Francis, Charles A. ,  Ge, Junhao ,  Xu, Yuan ,  Yao, Li ,  Back, Arthur ,  Zheng, Ying

IPC分类号： G02B1/04

CPC分类号： G02C7/04 ,  B65B5/04 ,  G02B1/043 ,  C08L83/12 ,  C08L33/08 ,  C08L33/10

摘要： Ophthalmically acceptably wettable silicone hydrogel contact lenses are described. The lenses are derived from a polymerizable composition including a first siloxane monomer represented by formula (1): wherein m of formula (1) represents one integer from 3 to 10, n of formula (1) represents one integer from 1 to 10, R 1 of formula (1) is an alkyl group having from 1 to 4 carbon atoms, and each R 2 of formula (1) is independently either a hydrogen atom or a methyl group, the first siloxane monomer having a number average molecular weight of from 400 daltons to 700 daltons; and a second siloxane monomer having a number average molecular weight greater than 7,000 daltons; wherein a total amount of siloxane monomers present in the polymerizable composition is from 30 unit parts to 50 unit parts; the lenses also include units derived from at least one hydrophilic amide monomer having one N-vinyl group that is present in the polymerizable composition in an amount from 30 to 60 unit parts. The lenses have ophthalmically acceptably wettable lens surfaces when fully hydrated. Batches of silicone hydrogel contact lenses and methods of making silicone hydrogel contact lenses are also described.

公开(公告)号：EP2492720A1

公开(公告)日：2012-08-29

申请号：EP12156774.7

申请日：2012-02-23

申请人： CooperVision International Holding Company, LP

发明人： Liu, Yuwen ,  Chen, Charlie ,  Francis, Charles A. ,  Ge, Junhao ,  Xu, Yuan ,  Yao, Li ,  Back, Arthur ,  Zheng, Ying

IPC分类号： G02B1/04

CPC分类号： G02C7/04 ,  B65B5/04 ,  G02B1/043 ,  C08L83/12 ,  C08L33/08 ,  C08L33/10

摘要： Ophthalmically acceptably wettable silicone hydrogel contact lenses are described. The lenses are derived from a polymerizable composition including a first siloxane monomer represented by formula (1):

wherein m of formula (1) represents one integer from 3 to 10, n of formula (1) represents one integer from 1 to 10, R 1 of formula (1) is an alkyl group having from 1 to 4 carbon atoms, and each R 2 of formula (1) is independently either a hydrogen atom or a methyl group, the first siloxane monomer having a number average molecular weight of from 400 daltons to 700 daltons; and a second siloxane monomer having a number average molecular weight greater than 7,000 daltons; wherein a total amount of siloxane monomers present in the polymerizable composition is from 30 unit parts to 50 unit parts; the lenses also include units derived from at least one hydrophilic amide monomer having one N-vinyl group that is present in the polymerizable composition in an amount from 30 to 60 unit parts. The lenses have ophthalmically acceptably wettable lens surfaces when fully hydrated. Batches of silicone hydrogel contact lenses and methods of making silicone hydrogel contact lenses are also described.

摘要翻译： 描述了眼科可接受的可湿性硅氧水凝胶隐形眼镜。 透镜衍生自包含由式（1）表示的第一硅氧烷单体的可聚合组合物：其中式（1）的m表示一个3至10的整数，式（1）的n表示1至10的整数，R 式（1）的1是具有1至4个碳原子的烷基，式（1）的每个R 2独立地为氢原子或甲基，第一硅氧烷单体的数均分子量为 400道尔顿至700道尔顿; 和数均分子量大于7,000道尔顿的第二硅氧烷单体; 其中存在于聚合性组合物中的硅氧烷单体的总量为30单位份〜50单位份; 透镜还包括衍生自至少一种具有一个N-乙烯基的亲水性酰胺单体的单元，其聚合组合物中存在的量为30至60单位份。 当完全水合时，镜片具有眼科可接受的可湿透镜表面。 还描述了硅胶水凝胶隐形眼镜的批次和制造硅酮水凝胶隐形眼镜的方法。

公开(公告)号：EP2492719A1

公开(公告)日：2012-08-29

申请号：EP12156772.1

申请日：2012-02-23

申请人： CooperVision International Holding Company, LP

发明人： Francis A Charles ,  Zheng, Ying ,  Xu, Yuan ,  Li, Yao ,  Back, Arthur ,  Hong, Ye ,  Chen, Charlie

IPC分类号： G02B1/04

CPC分类号： G02B1/043 ,  C08G77/20 ,  C08G77/46 ,  C08L83/04 ,  C08L101/14 ,  C08L51/085 ,  C08L101/04 ,  C08L83/00 ,  C08L83/12

摘要： Dimensionally stable silicone hydrogel contact lenses are described. The lenses are derived from a polymerizable composition including a first siloxane monomer represented by formula (1):

wherein m of formula (1) represents one integer from 3 to 10, n of formula (1) represents one integer from 1 to 10, R 1 of formula (1) is an alkyl group having from 1 to 4 carbon atoms, and each R 2 of formula (1) is independently either a hydrogen atom or a methyl group; the lenses also include units derived from a second siloxane monomer represented by formula (2):

wherein R 1 of formula (2) is selected from either hydrogen atom or a methyl group; R 2 of formula (2) is selected from either of hydrogen atom or a hydrocarbon group having 1 to 4 carbon atoms; m of formula (2) represents an integer of from 0 to 10; n of formula (2) represents an integer of from 4 to 100; a and b represent integers of 1 or more; a+b is equal to 20-500; b/(a+b) is equal to 0.01-0.22; the configuration of siloxane units includes a random configuration, the second siloxane monomer having a number average molecular weight of at least 3,000 daltons that is present in the polymerizable composition in an amount such that ratio of the first siloxane monomer to the second siloxane monomer is at least 2:1 based on unit parts by weight. Batches of silicone hydrogel contact lenses and methods of making silicone hydrogel contact lenses are also described.

摘要翻译： 描述了尺寸稳定的硅酮水凝胶隐形眼镜。 透镜衍生自包含由式（1）表示的第一硅氧烷单体的可聚合组合物：其中式（1）的m表示一个3至10的整数，式（1）的n表示1至10的整数，R 式（1）中的1是具有1至4个碳原子的烷基，式（1）的每个R 2独立地是氢原子或甲基; 透镜还包括衍生自由式（2）表示的第二硅氧烷单体的单元：其中式（2）的R 1选自氢原子或甲基; 式（2）的R 2选自氢原子或碳原子数为1〜4的烃基; 式（2）的m表示0〜10的整数， 式（2）的n表示4〜100的整数， a和b表示1以上的整数; a + b等于20-500; b /（a + b）等于0.01-0.22; 硅氧烷单元的构型包括随机构型，第二硅氧烷单体的数均分子量为至少3,000道尔顿，其存在于可聚合组合物中，其量使得第一硅氧烷单体与第二硅氧烷单体的比率在 至少2：1，基于单位重量份。 还描述了硅胶水凝胶隐形眼镜的批次和制造硅酮水凝胶隐形眼镜的方法。