COMBINATION STEROID AND GLUCOCORTICOID RECEPTOR ANTAGONIST THERAPY
    1.
    发明公开
    COMBINATION STEROID AND GLUCOCORTICOID RECEPTOR ANTAGONIST THERAPY 审中-公开
    组合类固醇和糖皮质激素受体拮抗剂治疗

    公开(公告)号:EP2661175A1

    公开(公告)日:2013-11-13

    申请号:EP12732354.1

    申请日:2012-01-06

    IPC分类号: A01N43/42 A61K31/44

    摘要: The present invention provides compositions of an anti-inflammatory glucocorticosteroid and a glucocorticoid receptor (GR) modulator useful for inhibiting glucocorticoid receptor induced transactivation without substantially inhibiting glucocorticoid receptor induced transrepression. Also provided are methods of treating a disorder or condition and reducing the side effects of glucocorticosteroid treatment, using the compositions of the present invention.

    摘要翻译: 本发明提供了用于抑制糖皮质激素受体诱导的反式激活而基本上不抑制糖皮质激素受体诱导的反式抑制的抗炎糖皮质激素和糖皮质激素受体(GR)调节剂的组合物。 还提供了使用本发明的组合物治疗障碍或病症并减轻糖皮质激素治疗的副作用的方法。