专利检索 ap:("Corcept Therapeutics, Inc.") AND inv:"COHAN, Pejman" 第 1 页

1.

发明公开
USE OF GLUCOCORTICOID RECEPTOR ANTAGONISTS IN COMBINATION WITH GLUCOCORTICOIDS TO TREAT ADRENAL INSUFFICIENCY 审中-公开
标题翻译：糖皮质激素受体拮抗剂联合糖皮质激素治疗肾上腺功能不全

公开(公告)号：EP3277281A1

公开(公告)日：2018-02-07

申请号：EP16774094.3

申请日：2016-03-30

申请人： Corcept Therapeutics, Inc.

发明人： MORAITIS, Andreas G. , COHAN, Pejman , BELANOFF, Joseph K.

IPC分类号： A61K31/496 , A61K31/5377 , A61K31/5375

CPC分类号： A61K31/567 , A61K31/437 , A61K31/473 , A61K31/513 , A61K31/575

摘要： This invention provides for a method of treating secondary adrenal insufficiency by co-administrating therapeutically effective amounts of a glucocorticoid and a glucocorticoid receptor antagonist to the patient in need thereof. In some embodiments, the method includes the proviso that the patient not be otherwise in need of treatment with a glucocorticoid and a glucocorticoid receptor antagonist. The treatment method can increase the patient's morning or basal cortisol level to at least about 12 μg/dL or a standard control level, and in turn, expedite significantly the recovery of the HPA axis. The method provided herein can improve health outcomes and life-threatening complications associated with secondary adrenal insufficiency.