专利检索 ap:("Corporation du Centre de Recerche du Centre Hospitalier de l'universite de Montreal") AND inv:"HAMET, Pavel" 第 1 页

1.

发明公开
USES OF OUABAIN AND OUABAIN-LIKE MOLECULES IN APOPTOSIS RELATED PATHOLOGIES 审中-公开
标题翻译：哇巴因类似的分子的细胞凋亡相关疾病中的用途

公开(公告)号：EP1196177A2

公开(公告)日：2002-04-17

申请号：EP00938367.0

申请日：2000-06-02

申请人： Corporation du Centre de Recerche du Centre Hospitalier de l'universite de Montreal

发明人： ORLOV, Sergei, N. , HAMET, Pavel , TREMBLAY, Johanne

IPC分类号： A61K31/704 , A61K31/7042 , A61P39/00 , A61P9/00 , A61P9/10 , A61P9/14 , A61P13/12 , A61P25/00 , A61P25/28

CPC分类号： A61K31/7048 , A61K31/704 , A61K31/7042

摘要： The inventation describes the use of ouabain or an ouabain-like molecule for protection against apoptosis in various organs or tissues. The compound acts by inhibiting the Na+, k+ pump, thereby inverting the physiologically low intracellular Na+/k+ ratio required for progression of apoptosis (e.g. in VSMC). Therefore, the molecule can be used to treat disorders of diseases due to increased apoptosis, such as cardiopathies myocardial ischemia/angina, infarct or infection, congestive heart failure, cns or neurodegenerative disorders, trauma, reperfusion injury, severe burn or renal failure.